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Background: Recruiting physicians and patients for primary care research is difficult, and low participation can greatly affect the validity of research. While practice-based research networks (PBRNs) offer advantages of scale for recruitment, the barriers are perennial. We designed a systematic process for recruiting physician-patient dyads in PBRNs and tested it in EXACKTE2, a large, cross-sectional, dyadic study.Methods: Based on known barriers, we designed a systematic process for recruiting dyads of family physicians and their patients and implemented it in 2 primary care practice-based research networks in Canada: one in Ontario (11 practices) and one in Quebec (6 practices). Dyads (one physician with one patient) were recruited simultaneously to explore their mutual influence during consultations. A key element of the process was a research assistant assigned to each practice. This person closely accompanied the recruitment process, liaising with staff and taking charge of interviews, questionnaires, and follow-up.Results: In total, 276 physicians and patients were recruited in 17 primary care practices in 2 primary care networks in Ontario and Quebec, representing a participation rate of more than 72% of eligible physicians and more than 64% of eligible patients.