Aims: The purpose of this study was to examine level of awareness about proper disposal of unused medicine. It is a growing problem. People directly dispose unused medicines into waste or flush into sink. Finally, these improperly disposed medicines mix with wastewater leach out into sea water, ground water, drinking water and effect human and other forms of life and develop microbial resistance and accidental poising and various societal repercussion. Confusion exists in people about proper disposal of unused medicine. Despite of already available guidelines people very rarely follow proper disposal methods. Particularly in developing countries situation is very alarming. It is well established fact that knowledge and level of awareness play pivotal role for practice of proper disposal methods. Study Design: This study was a descriptive cross-sectional study. Methodology: This study was conducted in Nawab Shah and its vicinities: Sakrand, Kaziahamed, Bachalpur, during September 2019 to May 2020. The number of participants were included in the study according Slovin's Formula. The simple random sampling method was used to select participants. The level of awareness about proper disposal of unused medicine of 400 participants was assessed through a well-designed questionnaire. The questionnaires were distributed to the participants at their homes with the help of volunteers. The descriptive statistics were analyzed through latest version of MS excel 2016. Results: Out of 400, 320 (80%) of the participants admitted have no knowledge for proper disposal of unused medicines. 185 (46.25%) of the participants viewed throwing unused medicines into waste was correct. Whereas 176 (44%) of the participants believed improperly thrown medicines has no effect on environment. Conclusion: The level of knowledge about proper disposal of unused medicine was found very low in study participants. It is suggested government should incorporate guidelines about the harmful effects of improper disposal of unused medicines in curriculum at primary level of education.