These results suggest that survivin may play an important role in carcinogenesis by stimulating tumor angiogenesis in human gastric cancer.

These results suggest that RON overexpression may help in predicting poor clinical outcomes in colorectal cancer.

BackgroundBlack tea has been shown to elicit anti-oxidant, anti-carcinogenic, anti-inflammatory and anti-mutagenic properties. In this study, we investigated the impact of black tea extract (BTE) on lipopolysaccharide (LPS)-induced NF-κB signaling in bone marrow derived-macrophages (BMM) and determined the therapeutic efficacy of this extract on colon inflammation.MethodsThe effect of BTE on LPS-induced NF-κB signaling and pro-inflammatory gene expression was evaluated by RT-PCR, Western blotting, immunofluorescence and electrophoretic mobility shift assay (EMSA). The in vivo efficacy of BTE was assessed in mice with 3% dextran sulfate sodium (DSS)-induced colitis. The severity of colitis was measured by weight loss, colon length and histologic scores.ResultsLPS-induced IL-12p40, IL-23p19, IL-6 and IL-1β mRNA expressions were inhibited by BTE. LPS-induced IκBα phosphorylation/degradation and nuclear translocation of NF-κB/p65 were blocked by BTE. BTE treatment blocked LPS-induced DNA-binding activity of NF-κB. BTE-fed, DSS-exposed mice showed the less weight loss, longer colon length and lower histologic score compared to control diet-fed, DSS-exposed mice. DSS-induced IκBα phosphorylation/degradation and phosphorylation of NF-κB/p65 were blocked by BTE. An increase of cleaved caspase-3 and poly (ADP-ribose) polymerase (PARP) in DSS-exposed mice was blocked by BTE.ConclusionsThese results indicate that BTE attenuates colon inflammation through the blockage of NF-κB signaling and apoptosis in DSS-induced experimental colitis model.

These results indicate that knockdown of RON inhibits AP-1 activity and induces apoptosis and cell cycle arrest through the modulation of Akt/FoxO signaling in human colorectal cancer cells.

Metastasis to the ampulla of Vater from renal cell carcinoma (RCC) is rarely encountered. We present the case of a 50-year-old male admitted with complaints of right upper quadrant pain and jaundice. The medical history consisted of a right radical nephrectomy, right adrenalectomy, and brain mass excision for RCC and metastasis. An esophagogastroduodenoscopy revealed a round ampullary mass with ulceration. An abdominal computed tomography scan revealed an enhancing mass in the ampulla of Vater, total pancreas, and left adrenal gland. Pathologic examination of a biopsy specimen was compatible with metastatic RCC of the clear cell type. A percutaneous transhepatic cholangiogram revealed complete obstruction of the distal common bile duct. A metal stent was inserted for bile drainage via the percutaneous transhepatic route. Patients with a history of RCC should undergo a careful long-term follow-up to detect and evaluate metastasis to usual and unusual sites.