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5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. This transformation initially showed low conversion, high impurity content and lack of reproducibility in lab trials. Parallel to process development, safety studies were conducted to investigate the stability of oxidant mixture, its composition and the oxidation reaction itself by reaction and adiabatic calorimetry. The resulting robust reaction conditions and appropriate safety boundaries allowed to develop a reproducible, safe protocol for the implementation of this chemistry on large scale, obtaining consistent results throughout the campaign.

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In the course of a general programme aimed to find new protocols for environmentally friend chemistry [1-3] we were looking for a clean, high yielding method of reduction of 5-nitrosalicylic acid (1) to 5-aminosalicylic acid (5-ASA) in industrial scale [4].[...]

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