Macrophages are key cellular components of the innate immunity, acting as the main player in the first-line defence against the pathogens and modulating homeostatic and inflammatory responses. Plasticity is a major feature of macrophages resulting in extreme heterogeneity both in normal and in pathological conditions. Macrophages are not homogenous, and they are generally categorized into two broad but distinct subsets as either classically activated (M1) or alternatively activated (M2). However, macrophages represent a continuum of highly plastic effector cells, resembling a spectrum of diverse phenotype states. Induction of specific macrophage functions is closely related to the surrounding environment that acts as a relevant orchestrator of macrophage functions. This phenomenon, termed polarization, results from cell/cell, cell/molecule interaction, governing macrophage functionality within the hosting tissues. Here, we summarized relevant cellular and molecular mechanisms driving macrophage polarization in “distant” pathological conditions, such as cancer, type 2 diabetes, atherosclerosis, and periodontitis that share macrophage-driven inflammation as a key feature, playing their dual role as killers (M1-like) and/or builders (M2-like). We also dissect the physio/pathological consequences related to macrophage polarization within selected chronic inflammatory diseases, placing polarized macrophages as a relevant hallmark, putative biomarkers, and possible target for prevention/therapy.

Aim: To evaluate the long-term outcomes of Acellular Dermal Matrix (ADM) with Coronally Advanced Flap (CAF) or Tunnel technique (TUN) in the treatment of multiple adjacent gingival recessions (MAGRs). Material and methods: Nineteen of the original 24 patients contributing to a total number of 33 sites for CAF and 34 for TUN were available for the 12 years follow-up examination. Recession depth, mean root coverage (mRC), keratinized tissue width (KTW), gingival thickness (GT) were evaluated and compared with baseline values and 6-months results. Regression analysis was performed to identify factors related to the stability of the gingival margin. Results: A highly significant drop in mRC was observed for both groups from the 6 months timepoint to the 12 years recall (p < .001). While there were no statistically significant differences between the two groups in terms of Clinical Attachment Level (CAL), KTW, GT changes and Root Coverage Esthetic Score at each timepoint (p > .05). KTW ≥ 2 mm and GT ≥ 1.2 mm at 6-months were two predictors for stability of the gingival margin (p = .03 and p = .01, respectively). Conclusions: A significant relapse of the gingival margin of MAGRs treated with CAF or TUN + ADM was observed after 12 years.

Objective: To evaluate and compare the skeletal vertical and sagittal effects of the Hyrax expander in Class I, II, and III patients. Materials and Methods: One hundred and eighty-three patients (91 females, 92 males) with a mean age of 8.7 years and with maxillary bilateral cross-bite and maxillary hypoplasia were analyzed retrospectively. They were divided into three groups according to their skeletal class. Sixty-five patients were skeletal Class I, 55 were skeletal Class II, and 63 were skeletal Class III. For each patient a lateral cephalogram was obtained before treatment and at the end of the retention period. Changes in the groups during the observation period were calculated, compared, and statistically analyzed with a t-test. Results: In terms of vertical effects, a statistically significant increase in the anterior vertical dimension was observed only in Class III patients. No statistically significant changes were observed in the posterior vertical dimension in any of the groups. In terms of sagittal effects, in Class I patients the maxilla and the mandible moved forward, but not in a statistically significant way, and the ANB angle showed a statistically significant decrease, but its change was less modified. In Class II patients the maxilla moved forward, but not in a statistically significant way, while the mandible moved forward in all of the patients in a statistically significant manner. The ANB decreased, statistically improving the skeletal classification. In Class III patients the maxilla moved forward in a statistically significant manner; the mandible showed a downward and backward rotation, improving the skeletal classification. Conclusions: The data obtained in this study permit us to confirm that rapid maxillary expansion can be used in all of the skeletal classes with good vertical and sagittal results. (Angle Orthod. 2011;81:298-303.)

The aim of this review is to describe the most commonly observed changes in periodontium caused by orthodontic treatment in order to facilitate specialists' collaboration and communication. An electronic database search was carried out using PubMed abstract and citation database and bibliographic material was then used in order to find other appropriate sources. Soft and hard periodontal tissues changes during orthodontic treatment and maintenance of the patients are discussed in order to provide an exhaustive picture of the possible interactions between these two interwoven disciplines.