This work contributes to the knowledge of historical contexts that have radically mutated over centuries and have lost their original characteristics. In these cases, information techniques and technologies can support the reconstruction of peculiarities in the digital domain and reveal their distinctive traits. This process applies to the architectural complex of Villa Farnesina in Rome, the realization of which involved the collaboration of influential artists from the 16th century; in particular, we focus on the Stables building, which no longer exists and can only be visualized by joining survey data, historiographic data, and metric measurements in digital and virtual assets. Starting from an integrated digital survey project, the paper highlights the potential of the graphic analysis of iconographic-archival and cartographic components for reconstructing a 3D model of the original appearance of the building. Furthermore, the correlation of geometric data and information parameters allows for the construction of a digital model to fulfill the demand for the transmission of interdisciplinary information to portray this jewel of Renaissance Rome to real and virtual tourism consumers.