In this article we investigate the innovation-sales growth nexus in Europe. We use data from European Innovation Scoreboard of the European Commission in the period 2000-2019 for 36 countries. Data are analyzed using Panel Data with Random Effects, Fixed Effects, Dynamic Panel at 1 Stage, Pooled OLS, WLS. Results show that the impact of innovation on sales in Europe is positively associated with "Share Knowledge-Intensive Services", "Turnover of Share Large Enterprises", "Employment Impacts", "Innovators", "Intellectual Assets", "Linkages" and is negatively associated with "Enterprise Births", "Government Procurement of Advanced Technology Products", "Share of Employment in High and Medium high-tech Manufacturing".