The subsequent primary cancer experience of 498 patients with major salivary gland carcinoma was evaluated using a life-table approach. Expected numbers were generated from two sources. These were population-based tumor registry data and an internal comparison group of randomly selected individually matched patients drawn from the same institution. Compared with either referent group, elevated risk ratios for all cancer sites combined were demonstrated. Risks for subsequent lung cancer were raised but were not statistically significant. For subsequent skin cancer, significantly elevated risks were noted.