Mycosis fungoides (MF) is an extranodal non-Hodgkin's lymphoma with primary involvement of the skin. The aim of the present study was to determine the incidence rate of MF in Isfahan (Iran) and to compare the results with other reports. We collected our data from the MF clinic of Alzahra Hospital which is the main center for treatment of MF patients in Isfahan (2007-2008). Eleven cases were reported to the MF clinic of Alzahra during the study, seven of which were diagnosed as MF. The incidence rate of MF in Isfahan in 2007-2008 was 3.91/1 million persons. The age spectrum was 28-80 years and the mean 43.14 years. The male : female ratio was 3:4. In conclusion, the incidence rate of MF in Isfahan (Iran) is similar to other areas. However, the male : female ratio is opposite to that of other studies.

Background:Factor V G1691A (FV Leiden), FII GA20210, and methylenetetrahydrofolate reductase (MTHFR) C677T mutations are the most common genetic risk factors for thromboembolism in the Western countries. However, there is rare data in Iran about cerebral venous and sinus thrombosis (CVST) patients. The aim of this study was to evaluate the frequency of common genetic thrombophilic factors in CVST patients.Materials and Methods:Forty consequently CVST patients from two University Hospital in Isfahan University of Medical Sciences aged more than 15 years from January 2009 to January 2011 were recruited. In parallel, 51 healthy subjects with the same age and race from similar population selected as controls. FV Leiden, FII GA20210, MTHFR C677T, and FV Cambridge gene mutations by polymerase chain reaction technique were evaluated in case and control groups.Results:FV Leiden, FII GA20210, and FV Cambridge gene mutations had very low prevalence in both case (5%, 2%, 0%) and control (2.5%, 0%, 0%) and were not found any significant difference between groups. MTHFR C677T mutations was in 22 (55%) of patients in case group and 18 (35.5%) of control group (P = 0.09).Conclusion:This study showed that the prevalence of FV Leiden, FII GA20210, and FV Cambridge were low. Laboratory investigations of these mutations as a routine test for all patients with CVST may not be cost benefit.

Systemic lupus erythematosus (SLE) is an autoimmune disorder with multifactorial etiology characterized by a high level of antibodies directed against nuclear and other cellular antigens, multisystem inflammation, relapsing, and a variable course and prognosis. 1,2 Over 90% of cases of SLE occur in women, frequently starting during reproductive age (range 20-30 years). However, the peak of disease incidence among males is more than the age of 45 years. 3 Most common SLE manifestations include renal involvement, arthritis, serositis, hematological, neurological, skin lesions, and oral ulcers. 1,4 Several pieces of research show that genetic factors have an important part in the incidence of SLE. Twin studies report a concordance rate ranging 24%-35% for monozygotic twins and 2%-5% for dizygotic twins. 5 On the other hand, there is the familial aggregation of SLE, which means people with lupus often have family members with SLE or other autoimmune conditions (10%-20% compared to 1% of controls). 6,7 Recently, genome-wide association studies (GWAS) reported multiple single nucleotide polymorphisms and novel rare variants in several genes which have an immunological function in correlation with SLE risk. For example, 1 study reported rare variations in 98 SLE-associated

Background: Colorectal cancer (CRC) is rated as the second cause of cancer death worldwide. Selenium (Se) has antioxidant activity and antitumor effect, especially in colon cancer. This important role occurs through selenoproteins. Low Se intake or low plasma Se and selenoproteins concentrations are associated with higher risk of CRC. rs7579 polymorphism in 3’ untranslated region of the SEPP1 gene can effect on selenocysteine incorporation during protein synthesis and also effect on microRNA –messengerRNA interaction and sequentially change in SEPP1 expression. rs34713741 polymorphism as a promoter variant in selenoprotein S ( SELS ) gene can effect on SElS expression and finally lead to increased CRC risk. Methods: A case–control study using 60 CRC patients and 74 noncancerous counterparts were undertaken in order to determine rs7579 and rs34713741 genotypes using real-time polymerase chain reaction high-resolution melting method. Results: We found an association of borderline statistical significance between allele A for rs7579 in SEPP 1 and CRC risk (adjusted odds ratio = 1.63; confidential interval = 0.99–2.07; P = 0.05). The frequency of genotypes rs34713741 of the mentioned polymorphisms was not significantly different between case and control groups ( P = 0.23 and P = 0.93, respectively). Conclusions: The results suggest that these polymorphisms probably has not a substantial role in Iranian CRC risk and is not a serious potential factor in risk assessment of mentioned disease among Iranians.

Background:Migraine is the most common chronic neurological disorders that may be associated with vasodilatation. According to the role of prostaglandin I2 (prostacyclin) receptor (PTGIR) in migraine as a receptor, which acts in vasodilatation, we decided to study the changes of PTGIR expression in migraine patients in relation to a suitable control group.Materials and Methods:Extracted mRNA from lymphocytes of 50 cases and 50 controls was used to synthesize cDNA. Real-time polymerase chain reaction was performed, and the data were analyzed. Our results show that PTGIR mRNA expression in cases was significantly higher than the control group (P = 0.010).Results:In conclusion, mRNA expression of PTGIR in the blood of people with migraines could be considered as a biomarker.Conclusion:In addition, repression of PTGIR gene expression by methods such as using siRNA is probably suitable for therapy of migraine patients.