Hypoxic ischemic encephalopathy (HIE) is a brain injury caused by inadequate cerebral blood flow, which occurs secondary to a hypoxic ischemic event during the prenatal, intrapartum, or postpartum time periods. Prime examples of hypoxic ischemic injuries can be divided into two categories: maternal risk factors and perinatal risk factors. Maternal risk factors include thromboembolic disorders, hypertension, infection, placental abnormalities, and illicit drug use. Perinatal risk factors include placental abruption, uterine rupture, cord prolapse, placenta previa, shoulder dystocia, etc. Severity ranges from mild with a full recovery to severe with long-term adverse outcomes. This is a serious complication of full term birth that affects approximately 1.5 to 2.5 neonates per one thousand live births [1]. In fact, an estimated 60% of infants affected by HIE will experience disabilities such as epilepsy, mental impairments, and cerebral palsy. Therapeutic hypothermia or body cooling, which decreases the metabolic demands of the body and minimizes brain sequelae, is a treatment option for neonates who meet specific inclusion criteria. PresentationClinical manifestations of HIE typically present within the postpartum period. Manifestations include abnormal heart rate tracings, abnormal arterial blood gas results, low APGAR scores, meconium stained amniotic fluid, decreased tone, depressed reflexes, seizure activity, and resuscitation