No abstract

Prevalence, symptoms, and treatment of depression suggest that major depressive disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is associated with depressive symptoms in male mice; however, this association is unclear in females. Here, we report that chronic social and subchronic variable stress promotes blood-brain barrier (BBB) alterations in mood-related brain regions of female mice. Targeted disruption of the BBB in the female prefrontal cortex (PFC) induces anxiety- and depression-like behaviours. By comparing the endothelium cell-specific transcriptomic profiling of the mouse male and female PFC, we identify several pathways and genes involved in maladaptive stress responses and resilience to stress. Furthermore, we confirm that the BBB in the PFC of stressed female mice is leaky. Then, we identify circulating vascular biomarkers of chronic stress, such as soluble E-selectin. Similar changes in circulating soluble E-selectin, BBB gene expression and morphology can be found in blood serum and postmortem brain samples from women diagnosed with MDD. Altogether, we propose that BBB dysfunction plays an important role in modulating stress responses in female mice and possibly MDD.

This article presents the results of a telephone survey regarding the conjugal and sex life of men and women from the Montreal region. Surprising as it may seem, the relationship between sexual and marital functioning within the couple has been the focus of little study to date. In fact, relatively little is known about the relationship among sexual behavior, sexual attitudes, sexual fantasies, and marital functioning. In this survey, a questionnaire covering these four variables was administered to 996 subjects chosen at random. The results indicate that women seem to have a more positive perception of their sexual behavior, whereas men seem to have a more positive perception of their marital life. Multiple regression analyses were run to examine the relationship between marital functioning and items related to sexual functioning. The links between sexual satisfaction and other items of the questionnaire concerning sexual behavior, sexual attitudes, and sexual fantasies were also analyzed. For this purpose, we subdivided the subjects into two age groups (under 60 and 60 and over) based on the loss of interest in sexual activity that the questionnaire allowed to discern in the 60+ group. The relationship between marital functioning and items related to sexual behavior proved statistically significant. Various items pertaining to sexual functioning also proved to be related to a global assessment of sexual satisfaction. Cognitive variables (sexual attitudes and sexual fantasies) were found to influence sexual satisfaction but had a lesser impact on marital functioning. Gender and age (under 60 or 60 and over) also had an effect on these relationships.

Premature ejaculation is the most-prevalent sexual problem in men. Various treatments have been developed to increase control over the moment of ejaculation, with two of the most frequent techniques used in behavior therapy being the squeeze method developed by Masters and Johnson (1970) and the "stop-and-start" technique described by Semans (1956). These treatments are effective and improve matters in most cases. However, couples can be averse to using them, with some women reluctant to squeeze their partner's penis and some couples unwilling to interrupt sexual interaction once initiated. Under a new functional-sexological treatment intended to improve control over the moment of ejaculation, men learn how to control their arousal without having to interrupt sexual activity. In this study, we compared three groups of couples in which the man suffered from premature ejaculation. One followed the new functional-sexological treatment, another followed a behavioral treatment--including the squeeze and stop-and-start techniques--and a control group was placed on a waiting list. We used several questionnaires to assess the effects of the various treatments. Moreover, subjects provided an objective measure of duration of intercourse from penetration to ejaculation. These measures were taken pre- and posttreatment and at three-month follow-up. We ran analyses of variance to assess the effects of the treatments. Results indicate that the new treatment is very effective. We observed significant improvements in duration of intercourse, sexual satisfaction, and sexual functioning. The subjects in the behavioral treatment group obtained similar results. Furthermore, subjects from both groups were satisfied with their respective treatment.