No abstract

Food deserts have been widely studied in Western contexts but rarely in transitioning economies and never within a rainforest. The Brazilian Amazon is a rapidly urbanizing region with high levels of poverty and food insecurity, providing an ideal context in which to explore this current research gap. Within this setting, five urban centers ranging from small town to metropole are examined to explore any potential variations between urban centers of different sizes and settings. A large survey was conducted with interviews in 554 food shops, assessing shop characteristics, food availability, price, and alternative household food acquisition strategies. Methods were developed to explore food deserts, accounting for food acquisition across multiple shops within a neighborhood. Insufficient access to healthy food was estimated to be widespread (42 percent of households), with access worse in smaller towns. Unlike many previous studies, local access to healthy food was not linked to neighborhood poverty and prices were generally lower in poorer areas. High levels of nonretail sourcing of food (e.g., fruit trees, fishing) in this region might lead to an overestimation of the food access problem if only retail food provision were considered. We conclude that food deserts are widespread in the rainforest cities studied, yet we highlight the importance of understanding local retail and nonretail food contexts. Finally, we question the extent to which the traditional food desert concept can be directly applied in the context of transitioning economies.

Plasmodium falciparum and P. vivax malaria parasites are now resistant, or showing signs of resistance, to most drugs used in therapy. Novel chemical entities that exhibit new mechanisms of antiplasmodial action are needed. New antimalarials that block transmission of Plasmodium spp. from humans to Anopheles mosquito vectors are key to OPEN ACCESSMolecules 2013, 18 9220 malaria eradication efforts. Although P. vivax causes a considerable number of malaria cases, its importance has for long been neglected. Vivax malaria can cause severe manifestations and death; hence there is a need for P. vivax-directed research. Plants used in traditional medicine, namely Artemisia annua and Cinchona spp. are the sources of the antimalarial natural products artemisinin and quinine, respectively. Based on these compounds, semi-synthetic artemisinin-derivatives and synthetic quinoline antimalarials have been developed and are the most important drugs in the current therapeutic arsenal for combating malaria. In the Amazon region, where P. vivax predominates, there is a local tradition of using plant-derived preparations to treat malaria. Here, we review the current P. falciparum and P. vivax drug-sensitivity assays, focusing on challenges and perspectives of drug discovery for P. vivax, including tests against hypnozoites. We also present the latest findings of our group and others on the antiplasmodial and antimalarial chemical components from Amazonian plants that may be potential drug leads against malaria.

No abstract

ABSTRACT-Species of the Annonaceae family are used all over the tropics in traditional medicine in tropical regions for the treatment of malaria and other illnesses. Phytochemical studies of this family have revealed chemical components which could offer new alternatives for the treatment and control of malaria. Searches in scientific reference sites (SciFinder Scholar, Scielo, PubMed, ScienceDirect and ISI Web of Science) and a bibliographic literature search for species of Annonaceae used traditionally to treat malaria and fever were carried out. This family contains 2,100 species in 123 genera. We encountered 113 articles reporting medicinal use of one or more species of this family including 63 species in 27 genera with uses as antimalarials and febrifuges. Even though the same species of Annonaceae are used by diverse ethnic groups, different plant parts are often chosen for applications, and diverse methods of preparation and treatment are used. The ethanol extracts of Polyalthia debilis and Xylopia aromatica proved to be quite active against Plasmodium falciparum in vitro (median inhibition concentration, IC 50 < 1.5 µg/mL). Intraperitoneal injection of Annickia chlorantha aqueous extracts (cited as Enantia chlorantha) cleared chloroquine-resistant Plasmodium yoelii nigeriensis from the blood of mice in a dose-dependant manner. More phytochemical profiles of Annonaceous species are required; especially information on the more commonly distributed antimalarial compounds in this family.