Background: Primary immunodeficiencies (PIDs) are rare genetic disorders leading to immunologic abnormalities that can affect different organs and systems. We determined the epidemiology, clinical, and geospatial characteristics of PID disorders among patients diagnosed over a 5 year period in a reference hospital covering a mesoregion in São Paulo, Brazil. Methods: A retrospective analysis of 39 patients with recognizable PIDs according to the criteria of the European Society of Primary Immunodeficiencies were enrolled. Thirty-four patients came from outpatient immunodeficiency clinics and five patients from active search. Demographic, clinical, and immunologic data were collected, and maps were constructed using a geographic information system. Results: The ratio of females to males was 1.4:1, and 48.7% of patients were younger than 17 years of age. The mean age at the onset of symptoms in children was 2.0 years [standard error of the mean (SEM), 1.7 years] and the diagnosis lag was 5.1 years (SEM, 3.1 years); the mean age at diagnosis in adults was 16.3 years (SEM, 11.8 years) and the lag was 10.8 years (SEM, 10.9 years). Antibody deficiency and common variable immunodeficiencies were the most common categories and phenotypes, respectively. The need for intravenous antibiotics and respiratory tract infections were the most prevalent warning signs, with an overall mortality rate of 15.3%. Autoimmune diseases were diagnosed in 56.4% and visceral leishmaniasis in 5.1% of patients. In the active search, 29 patients were investigated and 17.2% were diagnosed; early diagnosis, the involvement of multidisciplinary professionals, and dissemination of knowledge achieved milestone benefits. The distribution of PID networks in Brazil shows great asymmetry between regions and at a regional level; it was shown that the patients lived mainly in Presidente Prudente municipality. Conclusions: The implementation of an immunodeficiency outpatient clinic in a referral hospital covering a mesoregion with a large population has led to the generation of Boton Pereira et al. Epidemiologic, Clinical, Geospatial Approach to PID policies and practices to improve the diagnosis, quality of life, and care of patients with PIDs and their families. Furthermore, the search for hospitalized patients with warning signs for PIDs showed great benefits. Inequality in the distribution of PID network centers in Brazil was demonstrated.

RESUMOA Pneumonia é a principal causa de morte evitável por vacina. Considerando a carência de evidências acerca do impacto da vacina pneumocócica conjugada na pneumonia em crianças e tendo em vista a necessidade de integrar diferentes aspectos da introdução de uma vacina em uma determinada região, este estudo objetivou analisar o impacto da vacina nas internações hospitalares por pneumonia em crianças de 0 a 4 anos de idade, em Presidente Prudente no período entre 2008 a 2019. Trata-se de um estudo com delineamento observacional ecológico, em relação ao período avaliado, foram selecionados dois anos anteriores à inclusão da PCV10, o ano da implantação e os nove anos posteriores. Os dados sobre internações por pneumonia e número de doses aplicadas da vacina foram extraídos a partir dos sistemas de informações do Ministério da Saúde, disponibilizada via Departamento de Informática do SUS (DATASUS). Concluiu-se que a vacina reduziu a ocorrência de pneumonia.