Objective-Endothelial progenitor cells (EPCs) participate in vascular homeostasis and angiogenesis. The aim of the present study was to explore EPC number and function in relation to cardiovascular risk, gender, and reproductive state. Methods and Results-As measured by flow-cytometry in 210 healthy subjects, CD34ϩ KDR ϩ EPCs were higher in fertile women than in men, but were not different between postmenopausal women and age-matched men. These gender gradients mirrored differences in cardiovascular profile, carotid intima-media thickness, and brachial artery flowmediated dilation. Moreover, EPCs and soluble c-kit ligand varied in phase with menstrual cycle in ovulatory women, suggesting cyclic bone marrow mobilization. Experimentally, hysterectomy in rats was followed by an increase in circulating EPCs. EPCs cultured from female healthy donors were more clonogenic and adherent than male EPCs. Treatment with 17␤-estradiol stimulated EPC proliferation and adhesion, via estrogen receptors. Finally, we show that the proangiogenic potential of female EPCs was higher than that of male EPCs in vivo. Conclusions-EPCs

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Background. Childbirth medicalization has reduced the parturient's opportunity to labour and deliver in a spontaneous position, constricting her to assume the recumbent one. The aim of the study was to compare recumbent and alternative positions in terms of labour process, type of delivery, neonatal wellbeing, and intrapartum fetal head rotation. Methods. We conducted an observational cohort study on women at pregnancy term. Primiparous women with physiological pregnancies and single cephalic fetuses were eligible for the study. We considered data about maternal-general characteristics, labour process, type of delivery, and neonatal wellbeing at birth. Patients were divided into two groups: Group-A if they spent more than 50% of labour in a recumbent position and Group-B when in alternative ones. Results. 225 women were recruited (69 in Group-A and 156 in Group-B). We found significant differences between the groups in terms of labour length, Numeric Rating Scale score and analgesia request rate, type of delivery, need of episiotomy, and fetal occiput rotation. No differences were found in terms of neonatal outcomes. Conclusion. Alternative maternal positioning may positively influence labour process reducing maternal pain, operative vaginal delivery, caesarean section, and episiotomy rate. Women should be encouraged to move and deliver in the most comfortable position.

Light charged-particle emission and neutron emission have been measured for the fusionevaporation and fusion-fission channels in the Ni+' Mo reaction at 550 and 655 MeV bombarding energies. Temperatures, emission barriers, and multiplicities for the particles detected in coincidence with evaporation residues and fission fragments have been determined. For the evaporation residue data, the "first-chance" spectra of particles emitted from the compound nucleus have been isolated and the same initial temperature for the different evaporated particles has been extracted.The inverse level density parameter K = A /a reaches a value of 13.8+0.7 MeV at E,h --236 MeV.A decrease of the apparent emission barriers for the charged-particle emission at high excitation energy suggests dynamical effects on the de-excitation process. Analysis of the fissionlike events shows a saturation of light particle emission from the fission fragments. Using the average energies and multiplicities of the emitted neutrons, and charged particles, it has been found that for both initial excitation energies, 251 and 293 MeV, scission occurs at an excitation energy =140 MeV. For both fusion evaporation and fusion fission, the light charged particles are preferentially emitted during the early part of the de-excitation cascade. Statistical models and dynamical calculations have been used in an attempt to interpret the experimental data.