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Performing the segmentation of vasculature in the retinal images having pathology is a challenging problem. This paper presents a novel approach for automated segmentation of the vasculature in retinal images. The approach uses the intensity information from red and green channels of the same retinal image to correct non-uniform illumination in color fundus images. Matched filtering is utilized to enhance the contrast of blood vessels against the background. The enhanced blood vessels are then segmented by employing spatially weighted fuzzy c-means clustering based thresholding which can well maintain the spatial structure of the vascular tree segments. The proposed method's performance is evaluated on publicly available DRIVE and STARE databases of manually labeled images. On the DRIVE and STARE databases, it achieves an area under the receiver operating characteristic curve of 0.9518 and 0.9602 respectively, being superior to those presented by state-of-the-art unsupervised approaches and comparable to those obtained with the supervised methods.

Performing accurate and fully automated lung segmentation of high-resolution computed tomography (HRCT) images affected by dense abnormalities is a challenging problem. This paper presents a novel algorithm for automated segmentation of lungs based on modified convex hull algorithm and mathematical morphology techniques. Sixty randomly selected lung HRCT scans with different abnormalities are used to test the proposed algorithm, and experimental results show that the proposed approach can accurately segment the lungs even in the presence of disease patterns, with some limitations in the apices and bases of lungs. The algorithm demonstrates a high segmentation accuracy (dice similarity coefficient = 98.62 and shape differentiation metrics d mean = 1.39 mm, and d rms = 2.76 mm). Therefore, the developed automated lung segmentation algorithm is a good candidate for the first stage of a computer-aided diagnosis system for diffuse lung diseases.

An efficient approach for automatic detection of red lesions in ocular fundus images based on pixel classification and mathematical morphology is proposed. Experimental evaluation of the proposed approach demonstrates better performance over other red lesion detection algorithms, and when determining whether an image contains red lesions the proposed approach achieves a sensitivity of 100% and specificity of 91%.

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