Purpose The most frequent intraocular tumour are metastatic carcinomas. Although it is a rare entity, choroidal involvement is considered the most frequent intraocular malignancy due in part to its abundant vascularization. Although they are often the first manifestation of the tumour, they usually appear late in the course of a tumour disease and are associated with poor prognosis. The most frequent primary origin in the case of women is the breast and in the male the lung. Blurred vision or visual loss is the most common form of presentation. The therapeutic options include systemic treatments and local therapies such as radiotherapy or surgery among others. Methods Retrospective descriptive study conducted in our centre from May 2009 to May 2019 on patients diagnosed with choroidal metastases. We analysed the primary tumour origin, clinic at the beginning, initial presentation of neoplastic disease, therapeutic attitude and median survival. Results Of the 10 patients studied there were four males (40%) and six females (60%). The average age was 63.6 years. The initial presentation clinic was headache in four patients (40%), exophthalmos in two (20%), visual field reduction in one (1%), blurred vision in one (10%), retinal detachment in one (10%) and seizure in one (10%). As a primary source, pulmonary neoplasia was identified in four patients (40%) (two adenocarcinomas, one squamous and one small cell carcinoma), breast cancer in three patients (30%), adenocarcinoma of the pancreas in one patient (10%), papillary carcinoma of thyroid in one (10%) and high‐grade undifferentiated carcinoma in one (10%). Regarding the treatment received, six patients were candidates for palliative chemotherapy, one for radioactive iodine, one patient could not receive any type of treatment for death and two were candidates for local therapy by exantheration. Conclusions The results obtained in our sample are concordant with those found in the literature, obtaining a median survival of 10 months after the diagnosis of choroidal metastases. Choroidal metastases are a rare entity and generally associated with poor survival. The most commonly identified primary origins are carcinomas of the lung and breast. In a significant percentage of cases, choroidal metastases are the initial presentation of an unknown systemic neoplasm.

Purpose Orbital lymphomas are not frequent within orbital pathologies; they are commonly found associated to systemic diseases. Lymphomas affecting only the conjunctiva are even less frequent and their bilateral manifestation are uncommon. The characteristic lesion of conjunctival lymphomas is an orange‐pink mass at the bottom of the bag, without adhesion to deep planes. Patients are often asymptomatic but they may also complain of irritation of the eye. Painful proptosis or ptosis may appear if the affectation extends to the orbit. The average age of presentation is 60–70 years and it is more common in women. The diagnosis is confirmed by biopsy of the lesion. Methods We report the case of a 55‐year‐old woman with a conjunctival bilateral mucosa associated lymphoid tissue (MALT) lymphoma, not associated to systemic disease. The patient came to the service complaining of one month of epifora and itching in both eyes, with a salmon patch conjunctival mass in the temporal tarsal conjunctiva of the left eye, without any inflammatory signs or decreased visual acuity. Results A partial exeresis and biopsy of the left eye subconjunctival mass was performed. An extranodal lymphoma of the lymphoid tissue associated with mucosa was diagnosed (MALT lymphoma), CD20: positive, BCL2: positive and Ki67: 5%. Ocular ECO and MRI demonstrated infiltration of the external rectus muscle, being in contact with the superior rectus muscle, and PET CT confirmed a normal metabolic pattern. The patient was followed up for several months in the departments of Ophthalmology and Oncology, treatment was initiated with radical radiotherapy 30 Gy, fractionation cGy 200 in the left conjunctiva, which started on January 30 2017 and ended on February 18 2017. Conclusion Biopsy offers an early diagnosis for conjunctival lymphoma, being its prognosis very good. Because of this, ophthalmologists should be aware of this pathology, its characteristics and diagnosis.

Purpose Although uveitis‐glaucoma‐hyphema (UGH) syndrome was described as a postoperative complication associated with intraocular lenses (IOL) in the anterior chamber, cases with IOL in the posterior chamber have also been described in both into capsular bag, in sulcus as well as lenses anchored to the iris. The physiopathology is not clear but it seems that the mechanical friction produced by the IOL haptics, in contact with different structures, produces erosion, pigment dispersion and consequently anterior uveitis accompanied by elevated intraocular pressure (IOP) and hyphema. Different treatments have been proposed: topical or systemic drugs, YAG laser iridectomies, capsular tension rings, anti‐VEGF or IOL explantion. Methods We present the case of a 40‐year‐old man who came to our emergency department with painful red left eye and blurred vision since several hours. He had a history of left congenital cataract surgery when he was 14. The patient presented uveitis with elevated IOP that did not yield with topical treatment with mydriatics, corticoids, antihypertensive drugs and oral diuretic agent. 24 hours later, he showed hyphema, deciding to enter the hospital IV for treatment. Symptomatic control was achieved, being discharged with topical treatment. 15 days later he returned to A&E at the same clinic. He was treated in the same way and ultrasonic biomicroscopy (UBM) was performed. Results UBM demostrated a poorly positioned IOL.Then, we diagnosed him with UGH syndrome. After presenting a third episode a week after discharge, explantation exchange was decided. Since then it is in follow‐up and has not submitted incidents. Conclusion The increase in cataract surgeries implies that a growth of the possible associated complications.UGH syndrome must be taken into account in all those patients who present their characteristic triad. Before suspicion a UBM should be performed.

Purpose Our objective is to study in diabetic patients if there is an association between the presence of macular edema (diffuse or cystic) or not and the area of the foveal avascular zone (ZAF) in the superficial and deep retinal plexuses, diameters and the macular thicknesses measured with OCT and OCT‐A. Methods We performed a retrospective observational study with 13 diabetic patients (26 eyes). We have extracted general data of its history, characteristics about the evolution of its disease and ocular affectation, such as sex, age, time of evolution of diabetes, presence of diabetic retinopathy or not, treatments received and visual acuity. In each patient, on two images of OCT angiography (superficial plexus and deep plexus), we measured (with the “Triton” software) the area of the ZAF, as well as the larger diameter. In the classic OCT we have determined the central macular thickness and the type of macular edema: diffuse, cystic, or with neuroepithelial detachment at the foveal level due to the presence of subretinal fluid. We correlated the macular ischemia data of OCT‐A with the classical OCT data to see if there is any relationship. Results It is verified that all parameters have a higher value in patients who do have macular edema and that in one of the measured characteristics (the diameter of the superficial plexus) this difference is statistically significant. Finally, when observing the values of the effect size, it is verified that there are three parameters (FAZ Plexus superficial, Diameter of superficial plexus superficial and Diameter of deep plexus) where a higher clinical significance is obtained. Conclusions There is a positive association between the area and diameter of the ZAF and the presence of macular edema in diabetic patients.

Purpose IFN‐α2b has been postulated as an effective treatment to treat ocular surface tumors since the mid‐1990s. It could be used as a neoadjuvant agent, adjuvant therapy if there are positive margins after resection or as a primary agent for small tumors. It causes anti‐angiogenic, anti‐proliferative, cytotoxic and immunomodulatory effects. Consequently, it reduces the number of recurrences with few and mild side effects. Methods We present the case of a 77‐year‐old man with history of right eye cataract surgery who was seen in our Ophthalmology Department, due to a new appearance of a conjunctival tumor in the upper and lower temporal sectors, arriving at the bulbar conjunctiva with corneal invasion in the right eye. After performing a biopsy, squamous cell carcinoma with mild dysplasia was diagnosed. Ultrasonography and MRI were requested, ruling out infiltration. Surgical excision and amniotic membrane implantation were decided. Despite starting treatment with mitomycin C (MMC) 4 times a day, he suffered from a temporary recurrence. A second excision was performed 3 months later. This time, treatment with IFN‐α2b was started 4 times a day. Results IFN‐α2b is consolidating as a postoperative adjuvant treatment. In our case, it has managed to avoid new recurrences. We observed an asymmetric rise of the intraocular pressure (IOP) which could be associated with IFN‐α2b and need antihypertensive ocular topic treatment. Conclusion Nowadays, surgery remains the gold standard in the treatment of these tumors. Nevertheless, the high rate of recurrences and the appearance of different treatments makes search for an optimized treatment of these patients possible and necessary. IFN‐α2b stands out in terms of cost‐effectiveness and must be present among the therapeutic arsenal of any ophthalmologist who faces this carcinoma but it side effects should be studied.