Patients undergoing percutaneous coronary intervention procedures, as in patients with coronary disease, should receive treatment indefinitely with acetylsalicylic acid and clopidogrel. New brands of clopidogrel have been developed at lower costs, for helping to avoid premature suspension of antiplatelet therapy, as Cravid Leti Laboratories clopidogrel. Its effectiveness and safety must be compared with Plavix international standard. A prospective, comparative, cross-over, and randomized study was conducted in healthy volunteers. Each group received 1 tablet of Clopidogrel Leti or Clopidogrel Sanofi, 75 mg in a single dose daily for 7 days, followed by 7-day washout period before administration of second treatment. Platelet aggregation was measured at the start of each period and at 7 days of treatment through optical aggregometry, using an optical aggregometer 490-2D Chrono-Log, with a self-calibration system working with platelet-rich plasma with readings 0%-100% of light transmission. An important decrease of platelet aggregation was observed in both groups at 7 days of treatment of more than 50%, independent of adenosine diphosphate reactive (Helena and Chrono-Log) used for aggregation (P < 0.05). The relationship between the mean and 90% confidence interval ratio obtained with the 2 different adenosine diphosphate brands were between 80% and 125%, therefore, it can be considered that both brands are bioequivalent and perfectly exchangeable.

La demanda de cemento Portland (OPC) impacta de gran manera el medio ambiente, debido a la generación de gases de efecto invernadero y el consumo de materias primas no renovables durante su fabricación. Por tal razón, la búsqueda de materiales alternativos para disminuir el consumo de cemento es vital en la búsqueda de la sustentabilidad. Por esta razón, la escoria de cobre (EC) como materia cementicio suplementario (SCM) en la elaboración de morteros con menor contenido de OPC es una opción para generar un ambiente sostenible. Este estudio, investigo la influencia de la EC frente a la trabajabilidad, resistencia a la compresión y resistencia a la flexión a diferentes edades de curado. Morteros con 0%, 10%, 20%, 30%, 40% y 50% de EC como reemplazo parcial de OPC se elaboraron, donde se evidencio una mayor fluidez en los morteros con EC. Las propiedades mecánicas, se vieron afectas de manera monotónica en las primeras edades evaluadas (7, 28 y 90 días), donde los morteros con mayor contenido de EC presentaron la mayor perdida de resistencia. Sin embargo, a los 150 días de curado, la mezcla 10% EC presento una resistencia a la compresión de 43,6 MPa, 7,6% mayor que la mezcla de referencia.