In pursuing progress and economic growth, the Bolivian state led by President Evo Morales replicated the colonial division of labor through a development model known as neo-extractivism. Rooted tensions between indigenous communities and the state emerged due to the latter’s zealous economic bond with the extractivist sector. While the political economy of neo-extractivism has been considerably studied, how such tensions affect socio-political relations at the intersections of class, race, and gender remains underexplored and undertheorized. To address this research gap, this qualitative study posed the following research questions: How does neo-extractivism create gendered forms of accumulation by dispossession? And what forms of resistance emerge to challenge the impact of neo-extractivism among indigenous communities? By analyzing processes of social reproduction in Oruro, Bolivia, this study shows that neo-extractivism leads to the dispossession of indigenous lands and indigenous ways of life mainly through the contamination of water. Because indigenous peasant women are subsistence producers and social reproducers whose activities are water centric, the dispossession of water has a direr and gendered effect on them. Indigenous women and their communities, however, are not idle. Resistances against neo-extractivism have emerged. In parallel, the daily responsibilities of social reproduction within the context of subsistence agriculture, which are embedded in Andean epistemes of reciprocity, have allowed indigenous peasant women to build solidarity networks that keep the social fabric within and between communities alive. These solidarity networks provide important socio-political resources that are sites of everyday resistances that represent an ongoing threat and an alternative to capitalist, colonial, and patriarchal mandates.