Objective: to evaluate the effectiveness of the 50 IU/mL heparin solution compared to the 0.9% isotonic saline solution in preventing occlusion of the double lumen Hickman® catheter, 7 and 9 French, in patients undergoing hematopoietic stem cell transplantation. Method: a triple-blind randomized clinical trial. 17 double-lumen catheters (heparin group: n=7 and 0.9% isotonic saline group: n=10) were analyzed in which the two catheter routes were evaluated separately, totaling 34 lumens. The outcome variables were occlusion without reflux and complete occlusion. Descriptive analyses were performed using the Chi-square test and, of survival, according to the Kaplan-Meier test. Results: the mean number of days until the occlusion outcome was 52 in the heparin group and 13.46 in the 0.9% isotonic saline group in the white catheter route (p<0.001). In the red route, the mean follow-up days in the heparin group were 35.29, with no occlusion and 22.30 in the 0.9% isotonic saline group until the first occlusion (p=0.030). Conclusion: blocking with 50 IU/mL heparin solution is more effective than 0.9% isotonic saline in preventing occlusion of the Hickman® catheter. Brazilian Registry of Clinical Trials: RBR-3ht499.

HC/UFPR accounted for 46.0% of these procedures performed in Paraná. There were no significant variations in the sex distribution (p=0.788) and number of HSCT (p=0.213). 59.5% of the patients were from PR, 49.4% were between 0 and 17 years old, 79.9% were white, and 63.5% were male. The allogeneic HSCT was the most performed procedure (88.5%). 58.5% were hospitalized from 31 to 60 days (mean=37.6 days). 9.1% died. Acquired aplastic anemia was the most common underlying disease (31.9%). Conclusion: HSCT is a procedure of high cost and complexity. The study and the understanding of the determinants of its success are of extreme importance for the best planning, risk estimation and elaboration of public health policies.

Objetivo: verificar, por meio de estudos científicos, se a utilização de psicodélicos para o tratamento de transtornos psiquiátricos é uma estratégia eficiente. Materiais e Métodos: trata-se de uma revisão integrativa da literatura, cujo questionamento norteador para a investigação foi: “A utilização de psicodélicos, em doses apropriadas, é mais eficaz no tratamento de transtornos psiquiátricos em relação aos protocolos atuais?”. Foi realizada uma busca científica no mês de setembro de 2023 nas bases de dados Biblioteca Virtual de Saúde (BVS) e PubMed. Selecionaram-se três artigos para análise. Devido à escassez de publicações encontradas, a busca se expandiu por meio da análise das referências do artigo “Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials”. Ao final deste processo, três trabalhos recentes foram acrescentados, totalizando seis estudos para análise. Resultado: doses fracionadas de psicodélicos foram eficazes no tratamento de Depressão Maior, Transtorno do Estresse Pós-Traumático, Ansiedade, abuso indevido de álcool e heroína e outros transtornos de humor. Conclusão: novos estudos com metodologías mais homogêneas e com grupos amostrais mais amplos são necessários para determinar protocolos terapêuticos funcionais.