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ResumenLas bacteremias por microorganismos del genero Campylobacter son poco comunes en nuestro medio, debido a su baja incidencia y son escasos los reportes en la literatura. El siguiente reporte describe un caso de bacteremia por la especie Campylobacter fetus subespecie fetus, en un paciente de edad avanzada, quien presentó manifestaciones neurológicas que inicialmente desviaron el diagnóstico oportuno. Finalmente el paciente resuelve la infección tras el tratamiento antibiótico, sin complicaciones. Es de interés mencionar la presencia de este microorganismo como causante de diversas patologías en pacientes con inmunosupresión, considerándose un pató-geno oportunista, del cual no está bien definida su patogénesis ni la fuente de exposición o los factores de riesgo en estos pacientes. Igualmente, es importante la vigilancia activa de este microorganismo ya que por su complicada recuperación, altas exigencias nutricionales y su crecimiento lento, dificulta su aislamiento y diagnóstico en el laboratorio de microbiología. Palabras clave: Bacteremia, Campylobacter fetus, adulto mayor, Colombia. Bacteremia by Campylobacter fetus subsp. fetus in Colombia: Case Report AbstractThe bacteremias by microorganism of genera Campylobacter are uncommon in our medium, because of its low incidence and few reports in the literature. The report describe a bacteremia by Campylobacter fetus, a gram negative rod, spiral shape, in an older patient who presented initial neurogycal manifestations that shifted the timely diagnosis. Finally, the patient solves the infection after the antibiotic treatment, uncomplicated. It`s important to say that, this microorganism is the cause of different pathologies in patients with inmunosuppression considering as opportunistic pathogen. It`s pathogenesis source of exposure and risk factor in these patients has not yet been defined. Also, it is important the active surveillance in these microorganism, due to its complicated recovery, high nutritional requirements and slow growth. As described above is the reason because of its difficult isolation and diagnosis in the laboratory of microbiologic.Key words: Bacteremia, Campylobacter fetus, older patients, Colombia. IntroducciónEl género Campylobacter es conocido por su asociación con brotes de gastroenteritis aguda en los países desarrollados, debido a la ingestión de agua y alimentos contaminados [1][2][3][4][5][6] . Campylobacter fetus es un microorganismo inusual, pero es la especie de este género que clásicamente se reporta en infecciones extraintestinales, generalmente asociadas a bacteremia, y en menor grado a patologías entéricas. La bacteriemia por Campylobacter spp. es un hecho poco común, con una incidencia del 0.4-0.7% que en algunos casos puede pasar desapercibida y hasta puede no ser recuperado el agente microbiano con facilidad 7 . Este tipo de infecciones se han visto relacionadas especialmente a pacientes inmunocomprometidos, pacientes adultos de edad avanzada o pacientes con enfermedades crónicas 2 -4, 5-9 . Los agentes antimicrob...

BackgroundEarly and adequate antibiotic treatment are the cornerstones to improve clinical outcomes in patients with Bloodstream infections (BSI). Delays in appropriate antimicrobial therapy have catastrophic consequences for patients with BSI. Microbiological characterization of multi-drug-resistant pathogens (MDRP) allow clinicians to provide appropriate treatments. Current available microbiologic techniques may take-up to 96 hours to identify causative pathogens and its resistant patterns. Therefore, there is an important need to develop rapid diagnostic strategies for MDRP. However, rapid detection techniques are costly and are not widely available. We tested a modified protocol designed to detect Gram-negative bacilli (GNB) resistant to oximinocephalosporins and carbapenems from positive blood cultures.MethodsThis is a prospective, cohort study of consecutive patients with bacteremia. We developed a modified protocol using HB&L® system to detect MDRP. We then attempted to determine accuracy, concordance and reduction of identification time of this novel method in a reference hospital. Descriptive statistics and logistical regressions were used.ResultsNinety-six patients with BSI were included in the study. A total of 161 positive blood cultures were analyzed. Escherichia coli (50%, 81/161) was the most frequently identified pathogen followed by Klebsiella pneumoniae (15%, 24/161) and Pseudomonas aeruginosa (8%, 13/161). 32% of isolations had usual resistance patters. However, in 29/161 (18%) of identified pathogens were producer of carbapenemasases and 21/161 (13%) of extended-spectrum β-lactamases. Concordance among our HB&L® modified protocol and traditional method was 99% (159/161). Finally, identification times were significantly shorter using our HB&L® modified protocol than traditional methods (Mean, hours [SD], 20.8 [6.22] vs. 62.8 [6.22], P < 0.001).ConclusionHere we provided novel evidence that using our HB&L® modified protocol is an effective strategy to reduce the time to MDRP detection/identification; with a great concordance rate when compared with the gold standard. Further studies are needed to confirm these findings and to determine whether this method may improve clinical outcomes.Disclosures All authors: No reported disclosures.