The amplitude of goal-directed 10 degrees elicited saccades and the probability that the main saccade will be followed by multiple corrective saccades increased significantly for 10 subjects after Scopolamine treatment (0.5-mg intramuscularly injected). The results suggest a perceptual rather than a motor effect for the drug.

The effects of Scopolamine on the dynamics of saccadic eye movements, stimulated over a random time interval, have been investigated in humans. A 0.5-mg dose of the drug (intramuscular injection) had various influences on the basic saccadic parameters. For all subjects duration increased and peak velocity decreased, while for 50% of the subjects saccades became hypometric and latency increased. Standard deviation increased consistently too. Moreover, the Scopolamine treatment affected postsaccadic fixation; at the end of many saccades, the eye drifted considerably, but stability was recovered after a few seconds.

The perceptual alternation of the Necker cube, in its stationary phase, is studied as a function of the stimulus luminance down to the extreme condition in which the cones are completely inactivated so that the pattern of neural excitation reaching the primary visual cortex is very different from the normal one. No evident effect of luminance was found under passive observation either on the reversal rate or on the features of data distributions. Moreover, the complementary situation in which perception is based only on the cones does not affect the phenomenon either. These results permit the assumption that the perceptual alternation in its stationary phase, is a passive and automatic process, that is affected neither by a satiation of the first levels of the visual system nor by the psychological attitude of the subject consequent on dazzling the retina.

The altered feedback technique is very suited to display nonlinearities of the human smooth pursuit system. In fact, when the gain of the retinal feedback path is raised, for the horizontal channel, above its normal unitary negative value, a threshold is met beyond which sustained horizontal self-excited smooth oscillations of the eye can be observed, which point out the existence of a stable limit cycle. Furthermore, the characterizing features of both the transient and steady state show a well defined dependence on the total feedback factor K. In particular, the analytical dependence on K of the amplitude and frequency of limit cycle oscillations can be derived. Implications of the experiment with respect to the mathematical modelling of the system are discussed.

No abstract