Background: 18 F-FDG PET and CT radiomics has been the object of a wide research for over 20 years but its contribution to clinical practice remains not yet well established. We have investigated its impact versus that of only histo-clinical data, for the routine management of non-small-cell lung cancer (NSCLC).Methods: Our patients were retrospectively considered. They all had a FDG PET-CT and immuno-histochemistry (IHC) to assess PD-L1 expression at the beginning of the disease. A prognosis univariate and multivariate Cox survival analyses was performed for overall survival (OS) and progression free survival (PFS) prediction, including a training/testing procedure. Two sets of 47 PET and 47 CT radiomics features (RFs) were extracted. Difference between RFs according to PD-L1 expression, the histology status and the stage level were tested using suited non parametric statistical tests and the receiver operating characteristics (ROC) curve and the area under curve (AUC).Results: From 2017 to 2019, 212 NSCLC patients treated in our institution were included. The main conventional prognostic variables were stage and gender with a low added prognostic value in the models including PET and CT RFs. Neither PET nor CT RFs were significant to separate the different levels of PD-L1 expression. Several RFs differ between adenocarcinoma (ADC) and squamous cell carcinoma (SCC) tumours and a large number of PET and CT RFs are significantly linked to patient stage. Conclusions:In our population, PET and CT RFs show their intrinsic power to predict survival but do not significantly improve OS and PFS prediction in the different multivariate models, in comparison to conventional data. It would seem necessary to carry out one's own survival analysis before determining a radiomics signature.

No abstract

The clinical criteria for diagnosis of HS appear to be a family history with an autosomal dominant pattern of inheritance, early onset of facial rosacea-like dermatosis, and flexural multiple pigmented warty SK lesions. 2 Rosacea-like facial erythema is a distinction from Dowling-Degos disease (DDD, MIM179850, 615,327, and 615,696). 3 Our patients had the major clinical and pathological features of HS: early onset of a rosacea-like facial eruption characterized by erythema, telangiectasia, and follicular papules, multiple SKs on flexures; lack of flexural reticulate hyperpigmentation and comedone-like papules; histopathologically, down-growth of epidermal rete ridges in a filiform shape. Moreover, in the first family, the proband and her affected relatives presented with a varying degree of palmoplantar keratoderma, which is uncommon in DDD.In view of reports on genetic basis of DDD, 3,4 further KRT5, POFUT, POGLUT1,and PSENEN were detected by whole-exome sequencing in the cases from family 1. No mutations were found in these genes in our patients. Previous researches, 2 as well as our clinical and histopathological findings in addition to the genetic analyses, are supportive of HS as a distinct clinical entity rather than a genetic variant of DDD.In summary, we report two familial cases with a rosacea-like facial rash associated with early onset of flexural SK lesions, fulfilling the criteria both clinically and histologically for HS. Further clinical and genetic studies are required to reveal the etiology of HS.