Inicialmente três cães (6 olhos) foram submetidos ã injeções intracamerais de uma solução fisiológica saturada com micropartículas de grafite buscando-se a obtenção do glaucoma experimental. Ao final de 8 semanas constatou-se, de forma homogênea, glaucomas absolutos em todos os olhos. Na seqüência produziu-se, segundo este modelo, glaucoma em outros 9 cães (18 olhos), cada animal sendo submetido a dois tipos de cirurgia filtrantetrabeculectomia e iridencleise- e a dois tratamentos transoperatórios antifibróticos Mitomicina C e ácido acetil salicílico. As unidades experimentais assim constituídas foram estudadas clinicamente e histopatologicamente, com evidências aos 3, 6 e 12 meses de pós-operatório. O procedimento cirúrgico mais eficaz, independente do tratamento antifibrótico associado, foi a iridencleise, evidenciado por uma bolha de filtração patente um ano após a intervenção. O ácido acetil salicílico mostrou resultados antifibróticos superiores à Mitomicina C e ao contrário desta última, sem apresentar efeitos colaterais como globos hipotônicos. É lícito propor este novo modelo experimental de glaucoma para outras espécies por ser simples, barato, além de atuar como um "marcador" histológico do "caminho" do aquoso. Além disto poderá ser novamente empregado no cão visando testar outras técnicas de cirurgia filtrante e outros protocolos farmacológicos do glaucoma mas para sobretudo consolidar os estudos do uso do Ácido Acetil Salicílico como agente antifibrótico no olho. Abstract Experimental glaucoma was produced in all the eyes of three dogs by means of intracameral injections of physiological solution saturated with graphite microparticles. Homogeneous absolute glaucomas were then obtained by means of this technique. They were evidenced eight weeks after the intracameral injections. Following this experimental model, glaucomas were obtained in other 9 dogs. Each animal was subjected to two types of surgery, that is, filtration trabeculectomy and iridencleisis and by two antifibrotic topical treatments during the surgery with Mitomicin C and acetylsalicylic acid. Clinical and histopathologic evaluation of the experimental units were performed with emphasis in the third, sixth and twelve months after surgery. Iridencleise showed to be the most efficient surgical procedure in spite of being associated to the antifibrotic treatment. Acetylsalicylic acid displayed better antifibrotic activity than Mytomicin C showing no collateral effects as the formation of hypotonic globes for instance. This new glaucoma model may also be used for other animal species. Besides being simple and inexpensive it acts as a graphite histologic “marker” of the aqueous humor “path”. Moreover, it allows to be used in the dog in pharmacological tests as well as in other protocols of glaucoma filtration surgery, specially in studies regarding the use of acetylsalicylic acid as eye antifibrotic agent.

The use of powdered hemostatic products and propolis-based preparations has become increasingly common to control bleeding and aid healing. This study evaluated two hemostatic dressings, one based on propolis (Alveolex®) and the other on ferric subsulfate powder (Quick Blood Stopper®), on experimental wound in quails. The experiment was conducted with 36 quails assigned to three groups: control, propolis-based hemostatic dressing and ferric subsulfate-based hemostatic dressing, on two types of wounds, superficial (skin and subcutaneous) and deep (skin, subcutaneous and muscle). Pre- (day-7) and post-procedure (days 2 and 10) examinations showed a tendency to reduce hematocrit values on day 2 and a tendency to increase fibrinogen levels and total leukocyte count on the same day. Visual assessment of wound healing indicated that birds using Quick Blood Stopper® showed signs of poor healing, while the group treated with Alveolex® had uncomplicated healing within the expected time. The groups treated with hemostatic based on ferric subsulfate showed a tendency to increase the values of fecal corticosterone metabolites on day 10, suggesting an increased level of stress in these animals. During the surgical procedure, both hemostatic products controlled bleeding, but Alveolex®was more efficient and easy to handle.