172 Background: In the Phase III TROPIC trial ( NCT00417079 ), cabazitaxel/prednisone (CbzP) improved overall survival compared with mitoxantrone/prednisone in patients (pts) with mCRPC who had progressed on or after prior docetaxel (D) (HR 0.70; P < 0.0001). The survival benefit observed supported the establishment of 2 programs (based on local regulations): a compassionate use (CUP) and an early access program (EAP) ( NCT01254279 ). Methods: The aims of both programs are to provide drug to pts with mCRPC who may benefit from CbzP prior to commercial availability, and further evaluate CbzP safety profile. Total enrollment for both programs is targeted to be 1,600 pts from 250 centers in Europe, Asia, Latin America and Canada. Eligible pts will receive CbzP (25 mg/m2 Q3W plus oral prednisone 10 mg daily) until disease progression, death, unacceptable toxicity or physician/pt decision. Results: Baseline characteristics and safety data are available for the first 399 pts. Median age was 68 yrs (range 43–89); 90.2% were ECOG PS 0–1. Median cumulative dose of prior D was 675 mg/m2 (median 9 cycles). For pts whose disease progressed following D, the median time from last dose of D to progression was 4 months; 53.3% of pts experienced disease progression either during or < 3 months after D. 61% of pts had ≥ 2 metastatic sites; the most common were bone (93.2%) and regional lymph nodes (34.4%). A median of 4 cycles of CbzP was administered and 4 pts received ≥ 10 cycles. Median relative dose intensity was 99.2% (range 80.1–104.9). G-CSF was administered to 34.3% of pts in Cycle 1 (6.3% therapeutic, 26.6% prophylactic). Overall, 71.4% of pts experienced adverse events (AEs) (all grades) considered related to study drug. The most common Grade 3–4 AEs included neutropenia 11.3%, febrile neutropenia 6.3%, anemia 2.8%, fatigue 2%, neutropenic sepsis 1.8%, vomiting 1.3% and diarrhea 1%. 8 (2%) treatment-related deaths were reported. Conclusions: The CUP/EAP programs provide additional safety data for CbzP in a routine clinical practice population of pts with mCRPC. Treatment with CbzP was tolerable, with a manageable toxicity profile consistent with the data reported for the TROPIC trial.

Solid Rocket Motors frequently experience unsteady gas motions and combustion instabilities. Pressure oscillations are a well-known problem of large solid rocket motors (e.g. those of the US Space Shuttle, Arianne 5 P230 and P80). Pressure oscillations lead to thrust oscillations which can generate unstable dynamic environments for the rest of the launcher up to the payload. This kind of instability is governed by the flow behavior of the combusted gas combined with pressure fluctuations and acoustic resonances within the combustion chamber. In the present investigation a computational analysis of the combusted gases passing through the chamber of such a solid rocket motor has been conducted, with particular attention to Corner and Parietal Vortex Shedding instabilities, inside the core section of the motor together with a study of the associated pressure oscillations. Nomenclature Downloaded by Mario Panelli on July 18, 2017 | http://arc.aiaa.org |

Nowadays, worldwide environmental issue, associated to reduction of pollutant and greenhouse emissions are gaining considerable attention. Aviation sector contribution to the whole CO2 released accounts to around 2%, but it is expected to grow in the next future due to increase of demand. Probably, combustion engine design and fuel efficiency have already reached their optimum technology level and only a breakthrough as hybrid-electric propulsion could be able to satisfy the new international more demanding requirements. However, an improvement of the technology readiness level of hybrid-electric propulsion is strongly necessary and many operational and safety challenges should be addressed. In the work here reported, a hybrid-electric model was designed and developed for general aviation aircrafts, by means of the Mathworks® Matlab – Simulink 1D/0D simulation environment. Both thermal and electric energy storage units, transmission systems and power management devices were considered and the overall performances were evaluated during cruise phase and a conventional training mission, characterized by several run(lap) “touch-and-go”. Furthermore, an innovative mathematical methodology was implemented for battery pack discharge profile interpolation. Finally, reliability and accuracy of the new proposed model were evaluated through comparison with the commercial code Simcenter AMESim® software and an average bias only equal to 5% was achieved.