If the implants are positioned at the level of the alveolar bony crest, the platform-switching concept may have a minor impact on the length of the epithelial attachment (0.84 vs. 1.91 mm), while the connective tissue adaptation compartment remains relatively unaffected. Moreover, platform switching resulted in less resorption of the alveolar crest (0.58 mm).

The nasopalatine duct cyst (NPDC) is the most common of the non-odontogenic cyst of the jaws. This cysts are usually central or unilateral with no prevalence of side occurrence. The NPDC is the most frequent developmental, nonodontogenic cyst of the jaws. This cyst originates from epithelial remnants from the nasopalatine duct. The cells could be activated spontaneously during life, or are eventually stimulated by the irritating action of various agents (infection, etc.). Generally, patients present without clinical signs and symptoms. Therefore, the tentative diagnosis "nasopalatine duct cyst" is often based on a coincidental radiological finding on a routine panoramic view or occlusal radiograph. The definite diagnosis should be based on clinical, radiological and above all histopathologic findings. The therapy of nasopalatine duct cysts consists of an enucleation of the cystic tissue, only in rare cases a marsupialization needs to be performed. This report describes the appearance and treatment of a rare case of bilateral nasopalatine duct cyst.

The influence of salinity on toxicity outcomes has been demonstrated for various contaminants, but has received limited attention for endocrine disrupting chemicals (EDCs). Short-term laboratory tests using small-bodied fish are an important tool for evaluating impacts of EDCs on reproduction. Tests have been developed for both freshwater and estuarine/marine species, providing an opportunity to assess whether concentrations at which small-bodied fish respond to EDCs may be influenced by salinity. We conducted a semi-quantitative review of short-term laboratory tests with small-bodied fish exposed to EDCs, including 59 studies under freshwater conditions (7 species) and 23 studies conducted under saline conditions (5 species). We focused on two model estrogens [17α-ethinylestradiol and 17β-estradiol (E2)], and three androgens (17β-trenbolone, 5α-dihydrotestosterone and 17α-methyltestosterone). The lowest observed adverse effect concentration (LOAEC) for key reproductive endpoints was recorded, including sex-steroid and vitellogenin (VTG) levels, fecundity and fertilization. In 65.2% of cases, responses occurred at lower doses under freshwater compared to saline conditions, compared to only 4.3% of cases where fish responded to lower doses under saline conditions. The potential influence of salinity was more pronounced when estrogenic compounds were considered separately, with fish responding to lower doses under fresh compared to saline conditions in 90.5% of cases. Fecundity and E2 level were identified as the most sensitive endpoints for evaluating EDCs regardless of salinity. Interestingly, female VTG levels were a sensitive endpoint under freshwater but not saline conditions. Overall, our results suggest that salinity may be an important factor influencing how small-bodied fish respond to environmental EDCs.

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