This study provides evidence that GSH is a promising drug for the prevention of oxaliplatin-induced neuropathy, and that it does not reduce the clinical activity of oxaliplatin.

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CDDP-induced anemia is corrected by rHuEPO, which results in reduced blood transfusion requirements.

Sry Octreotde, a somastain analoue, has been shown to inhibit the growth of strointestinal cancrs n vro and in vio. To al., 1982;Hudd et al., 1989;Townsend et al., 1989). The mehanism of action is not well known but is probably mediated by speific hormone receptors present in normal and tumour cells; thus there have been efforts to develop receptor antagonists as anti-cancer agents (Chang et al., 1986;Singh et al., 1986).One of the most important naturally occurring antiproliferative hormones is somatostatin. It has been shown to inhibit cellular proliferation in normal and neoplastic mucosa of stomach, pancreas and colon-rectum (Reichin, 1983).However, the short half-life of native somatostatin and the need for its intravenous administration makes long-term somatostatin therapy impactical (Sheppard et al., 1979).Octreotide, a synthetic somatostatin analogue, differs from natural somatostatin, which has a half-life of 1-3 in that it has higher potency and a much longer half-life (Bauer et al., 1982

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