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involves the hypothalamus, the pituitary gland, the ovaries, the adrenal gland and the peripheral adipose tissue creating an imbalance associated with three characteristic symptoms: oligoanovulation, hirsutism and infertility. The diagnostic criteria are based on Rotterdam consensus that includes the following three features: oligo-anovulation, clinical or biochemical signs of hyperandrogenism, polycystic-appearing ovaries at ultrasound examination, characterized by the presence of 12 or more follicles with diameter of 2-9 mm in each ovary, and/or increased ovarian volume (>10 ml). At least two of them have been fulfilled in order to make the diagnosis.Despite several studies on PCOS, its patho physiology remains unknown although various etiological factors are suspected to be involved. Particularly insulin resistance and compensatory hyperinsulinemia seem to be central in PCOS onset, in addition to genetic and environmental causes. containing inositol (mainly myo-inositol plus D-chiro-inositol at the physiological plasma ratio of 40:1) are highly recommended.