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By condensing the potassium salt of isatinic acid -(0-aminopheny1)-glyoxylic acid -with urea, A;-substituted ureas and ethyl carbamate, 2-hydroxyquinazoline-4-carboxylic acid was obtained, in excellent yield. In a similar condensation with guanidine, potassium isatinate reacted quantitatively t o give 2-aminoquinazoline-4-carboxylic acid. Various derivatives were obtained from these new acids by methylation and decarboxylation reactions.Only a small number of 2-alkyl-and 2-aryl-quinazoline-4-carboxylic acids (11) are known 192. They were all prepared in the same way, i.e. by condensing ammonia with N-acylated isatinic acids (I). When reported, the over-all yields -starting from isatins or o-aminoacetophenone -appear to be rather low. Quinazoline-4-carboxylic acid itself has not been synthesized hitherto.

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