Hemodynamic and autonomic responses have been used as sensitive indicators of cardiovascular health in situations involving emotions. However, few studies evaluated these indicators when feelings result from vicarious experiences. This research aimed to verify if empathy measures would be associated with variations in blood pressure, heart rate, rate pressure product, and heart rate variability in young adults, after exposure to experimental situations. Results point out that hemodynamic and autonomic cardiac indicators were associated with dispositional and situational empathy. These results are discussed based on Martin Hoffman's theory and in the light of recent findings in the field of Psychophysiology.