Lipid profile abnormalities at birth indicate that initial genetic inheritance is already at risk of developing a cardiovascular disease. Investigate the profile of umbilical cord blood lipids of term newborns in Parakou (Benin). This research work was a cross-sectional study with descriptive and analytical purpose, based on prospective collection of data. It involved term newborns recruited through complete census in three health-care facilities located in the city of Parakou (Republic of Benin), after the informed consent read and approved by their respective mothers and ethics advice. The study data were collected from March 1 to May 30, 2017 by measurements of anthropometric and lipid parameters from umbilical cord blood using endpoint enzymatic methods. LDL cholesterol was obtained by Friedewald formula. A total of 120 newborns were recruited (60 males and 60 females). Their mean weight was estimated at 2992.68 ± 355.08 g with extremes from 2120 to 3125 g. The mean values of lipid parameters were: total cholesterol (0.68 ± 0.25 g/L), HDL cholesterol (0.29 ± 0.12 g/L), LDL cholesterol (0.31 ± 0.16 g/L) and triglyceride (0.39 ± 0.27 g/L). There was no significant difference in mean values of newborns ’ lipid parameters between both sexes (p > 0.05). Total cholesterol and HDL cholesterol were normal, respectively in 75.83% and 85% of cases; hypotriglyceridemia was observed in 61.67% of newborns.