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INTRODUCTION: Linear morphea is rare localized form of scleroderma. The lesions are characterized by localized hard/smooth ivory-coloured immobile areas of skin. The appearance is hidebound skin, known as andrew's disease of skin. These linear lesions often develop along the line of blaschko. METHOD: A cross-sectional,hospital-based clinical study of patients with linear morphea attending the Outpatient Department of tertiary care centre was done over a span of 3 months. Detailed history was taken along with clinical examination. After counselling and after recording their consent, skin biopsy done along with routine investigations and results were evaluated. RESULTS: We have come across six cases in 3 months. Age group ranged from 10-20 years with 2 male and 4 female patients. Average age of onset was 14.5 years. Two cases had lesions involving limbs, two had lesions on forehead and one patient had extensive lesions involving entire right half of body including face. Serum ANA titre was positive in one case,which also showed changes in CT scan and bone scan. EEG changes were seen in two out of three cases of facial lesions. Skin biopsy in all cases were consistent with morphea. CONCLUSION: Though linear morphea is a local disorder without systemic association generally,patients with Serum ANA positivity and EEG changes in facial lesions need to be observed for permanent CNS damage if not counteracted with immunosuppressives. As it has higher morbidity and predilection in younger population,cosmetic and functional disability caused by it affects the quality of life.

Objective: Children with nephrotic syndrome (NS) have a stressful condition, and oxidative damage may impair their treatment response. This study aims to gain a better understanding of the relationship between oxidative stress and NS to lay the basis for further research into improved diagnostic options, treatment, and prevention of the disease. Methods: We took a blood sample from 100 Indian patients aged 2-14 y. Each patient was tested for oxidative stress. The buege method was used to assess MDA levels in patients. The pyrogallol method was used to measure SOD activity in blood serum, and the jollow method was used to measure glutathione levels. Results: The levels of oxidative stress markers (MDA, SOD, and GSH) were compared between NS patients and the control. SOD and GSH concentrations were significantly decreased in the NS group when compared to the control. In contrast, MDA level was significantly higher in the NS group than in the control. In the correlation analysis, we found that the serum SOD activity was significantly positively correlated with serum albumin and creatinine level in patients with NS. Thus, oxidative stress in children with NS is indicated by reduced antioxidant potential because of low albumin. Therefore, it is thought that oxidative stress is implicated in the development of NS in Indian children. Conclusion: We concluded that oxidative stress was intensified in children with NS due to decreased antioxidant levels caused by hypoalbuminemia.

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