No abstract

SummaryBackground: It is assumed that not only leukocytosis, but also the activation of white blood cells (WBC) may play a role in the pathogenesis and prognosis of patients with myocardial infarction (MI). Activation of WBC includes upregulation of CDI lb\CD18 and downregulation of CD62L (Lselectin) antigens.Hypothesis: The activation of WBC is associated with the appearance of a larger MI.Methods: CDl1 b\CD I8 and CD62L were measured on the surface of WBC on Day 1 and Day 3 from the onset of MI. The size of the infarct was estimated by calculating the area under the curve of the creatine kinase enzyme, which was measured every 6 h.Results: A negative correlation was noted between the absolute polymorphonuclear count and the availability of the CD62L on these cells during Day 1 (r = -0.46, p = 0.003) and Day 3 (r = -0.3.5, p = 0.05). There was a positive correlation between the size of MI and the WBC count (r = 0.46, p = 0.004) and a negative correlation with CD62L on polymorphonuclears (r = -0.35, p = 0.03). During Day 3, the CD1 lb\ CD 1 8 on the polymorphonuclears increased despite a decre-