The duration of tuberculosis treatment affects patient adherence. The pharmacist monitors the patient's medication by providing an intervention in the form of a reminder card. The research objective was to use a reminder card to determine the compliance level of tuberculosis patients. The design of this study was a pre-experimental one group pretest-post test from December 2019 - January 2020. The study sample was 133 adult tuberculosis patients who received detached drugs and had undergone treatment >1 month at the Pulmonary Poly Outpatient Waluyo Jati Kraksaan Hospital. The level of adherence with the reminder card intervention was calculated using the pill count method and analyzed using the Wilcoxon test. The result of tuberculosis patient adherence level increased significantly (p<0.05) after giving the reminder card from 50.00% to 99.37%. Providing a reminder card is an effort that can improve adherence to treatment of tuberculosis patients.

Terapi pasien skizofrenia seringkali dimulai dengan pengobatan. Selain terapi dukungan psikososial, pengobatan untuk gejala skizofrenia dapat menggunakan kombinasi obat antipsikotik. Penggunaan kombinasi obat antipsikotik menimbulkan berbagai efek samping maupun interaksi obat yang berpengaruh terhadap kualitas hidup pasien. Tujuan penelitian ini untuk mengetahui hubungan kualitas hidup terhadap kombinasi obat antipsikotik di Puskesmas Sumberpucung. Desain penelitian menggunakan cross sectional secara retrospektif dengan uji statistik deskriptif dan chi square. Terdapat 37 responden yang terbagi menjadi 16 responden menggunakan kombinasi A (klorpromazin, haloperidol) dan 21 responden menggunakan kombinasi B (Haloperidol, Triheksifenidil), (Klorpromazin, Triheksifenidil, Trifluoperazin), (klorpromazin, Triheksifenidil, Haloperidol), (Haloperidol, Klozapin), (klorpromazin, Risperidon), (Triheksifenidil, Risperidon), (Triheksifenidil, Trifluoperazin, Klozapin), (Triheksifenidil, Risperidon, Klozapin), (Klorpromazin, Triheksifenidil, Risperidon), (Haloperidol, Triheksifenidil, Trifluoperazin), (Haloperidol, Trifluoperazin). Wawancara responden terkait kualitas hidup menggunakan kuesioner WHOQOL-BREF yang terbagi dalam 4 domain. Masing-masing domain dianalisis berdasarkan baik dan buruknya kualitas hidup, riwayat penggunaan obat antipsikotik ditinjau dari 3 bulan sebelumnya. Kuesioner telah tervalidasi dan reliabel. Hasil penelitian menunjukkan terdapat hubungan antara kualitas hidup terhadap penggunaan kombinasi obat antipsikotik (p<0,05). Berdasarkan hasil penelitian didapatkan kombinasi B memberikan kualitas hidup yang lebih baik dikarenakan kombinasi B memiliki efek samping yang lebih ringan untuk mengatasi gejala pada pasien skizofrenia.

Introduction: The adverse drug reaction (ADR) is 4-7 times more common in elderly patients.  That was also related to changes in pharmacokinetics and pharmacodynamics that triggered the emergence of Drug-Related Problems. Objective: The purpose of this study was to assess ADR in elderly patients with chronic diseases using the GerontoNET Score and the Screening Tool of Older People's Prescriptions (STOPP) criteria.  Methods: The research design used a cross-sectional study which was analyzed descriptively. The sample consisted of 72 patients, aged more than 60 years, accompanied by chronic diseases, and hospitalized at Waluyo Jati Kraksaan Hospital. The exclusion criteria were patients referred to the Intensive Care Unit.  Assessment to see the risk of ADR in elderly patients with chronic diseases using the GerontoNet Score while the wrong type of drug is given to elderly patients using the STOPP criteria. The variables contained in the GerontoNET Score are comorbid conditions ³4 (score= 1), heart failure (score= 1), liver disease (score = 1), the number of drugs such as: £5 (score= 0); 6-7 (score=1); ³8 (score=4), history of ADR (score=2), kidney failure (score=1).  Results: The variable with the most ADR risk factors was the number of drugs ³8 drugs as many as 47 patients (65.3%) with GerontoNET score ³4 as much as 70.8%.  The types of drugs included in the STOPP criteria are clopidogrel, Arixtra (fondaparinux), beta-blockers, NSAIDs, and furosemide.  Conclusion: The risk factor for ADR was the number of drugs ³8 drugs.

Keanekaragaman hayati Indonesia dapat dimanfaatkan sebagai obat, obat tradisional, kosmetik dan makanan. Senyawaantioksidan banyak ditemukan pada tumbuhan, baik pada bunga, daun maupun buah. Saat ini sudah banyak sekali produk kecantikan yang menggunakan bahan alami. Selain lebih aman, bahan-bahan alami juga dipercaya dapat mengatasi masalah kulit dengan lebih baik daripada bahan-bahan kimia. Tumbuhan yang mengandung senyawa bioaktif flavonoid dapat digunakan sebagai obat potensial untuk mencegah stres oksidatif. Tujuan dari penelitian ini adalah untuk mengetahui ekstrak tumbuhan apa saja yang dapat digunakan untuk mencegah stres oksidatif pada kulit manusia dengan kandungan antioksidan yang dimilikinya, mengetahui cara kerja antioksidan dalam mencegah stres oksidatif serta mengetahui tumbuhan mana yang memiliki nilai kandungan antioksidan paling baik menggunakan metode Literature Review. Metode Literature Review menjadi modal untuk membandingkan dan mempertentangkan hasil penelitian sendiri dengan hasil-hasil penelitian yang pernah dilakukan orang lain. Dari hasil penelitian dan sesuai kriteria inklusi yang ada, menunjukkan bahwa terdapat 14 macam tumbuhan yang memiliki kandungan antioksidan. Dengan adanya kandungan antioksidan yang terdapat pada tanaman, antioksidan dapat bekerja guna mencegah adanya stres oksidatif pada kulit manusia dengan cara pemutusan rantai radikal bebas yang ada di dalam sistem dan melibatkan penghilangan ROS dengan memadamkan katalis pemrakarsa rantai. Zingiber officinale Rosc. (rimpang jahe) dengan nilai IC50 sebesar 8,29 ± 1,73 ppm dan Ixora javanica flower (bunga soka jawa) dengan nilai aktivitas pemulungan radikal (radical scavenging activity) sebesar 80% diketahui memiliki nilai kandungan antioksidan paling baik.

The pandemic of COVID-19 has forced pharmacist assistance practitioners to strive to improve their qualifications and competencies, especially in molecular biology. The human resources competencies in this field are still lacking, resulting in some obstacles in the handling of COVID-19 encountering, thus hampering the acceleration of post-pandemic recovery. The Virus that can spread rapidly requires competent health workers to move as quickly as possible to overcome this pandemic condition. Ignorance of these critical technical matters often occurs so that it affects the identification results, which are expected to be more accurate, precise, and reliable. In a workforce to increase the competency capacity of pharmacist assistants in the biomolecular field, especially in the technical competence of genetic material isolation and PCR methods, the Pharmacy Study Program of Ma Chung University held Webinars and Workshops related to DNA isolation and quality testing. The webinar and workshop on the isolation of genetic material were carried out to implement one of the research topics in the Pharmacy Study Program, especially in the field of development of molecular biology. The essential thing in this webinar and workshop is discussing some critical criteria before the actual virus identification. This program collaborates with PAFI (Indonesian Pharmacy Experts Association) of Batu City as a partner. People who took part in this event consisted of 63 persons from the Batu City and Malang City areas. Most of the participants work in health facilities, with 50% of the participants having isolated genetic material and PCR (Polymerase Chain Reaction). Spreading the pre and post-test with the same questions increased the average acknowledgment score from 42.9 to 61.1. This indicates that continuous training in this field needs to be held on an ongoing program so that the competence of pharmacists in the field of molecular biology is getting better.