Malignant transformation of the normal somatic cells into tumorous ones can be assisted by the very difference in their nature agents and factors: penetrating radiation of different nature, numerous chemical substances, some oncogenic and infectious viruses, some toxins, pharmacological agents, some kind of irritation and some non-carcinogenic substance. Probably, the above-numerated agents and factors start up some a common mechanism of the conversion of normal cells into transformed state. As shown, carcinogenic potencies of some fatty acids, carbohydrates, and even distilled water and saline may be explained from the standpoint of karyogamic theory of carcinogenesis. All above-mentioned substances may induce perforations of different volume of plasma membranes of somatic cells. This may premise for cells' fusion process. In result of perforations, total negative charge of plasma membranes decrease, and the somatic cells acquire the capability of contacts with each other, which upon coincidence of the perforated sites of these organoids, may serve as a prerequisite to fusion process.

No abstract

Normal somatic cells sensitive to carcinogenic effects and capable of proliferation form firstly a binuclear cells (dikaryons) and then hybrid cells (mononucleated synkaryons) by means of fusion with another cells of the same organism, in particular with differentiated and non-differentiated cells of corresponding tissue or with cells capable to migrate. In all probability, during the perforation of the plasma membrane, i.e., after the formation of po­res, induced by different carcinogenic (and noncarcinogenic) agents and factors, the total negative charge of plasma membrane changes (decreases) and the cells develop the ability to come closer to each other, whi­ch will probably be the prerequisite to a fusion process. On the other hand, it is not excluded that perforation can assist the fusion of only neighboring cells. Initially, a set of chromosomes in a precancerous cell retains, even for a short time, the condition of tetraploidy. Because of cell fusion generates tetraploidy, it potentially might cause chromo­somal instability. The article emphasizes a possibility of using the fusion process in different aspects of carcino­genesis (therapy, prevention, etc.).

No abstract