It is well established that cytokine storm is associated with more severe clinical course of COVID-19. Many clinical findings of COVID-19 and other severe viral infections (e.g. fever, muscle pain, respiratory distress, cough), are directly attributed to cytokine storm. For example, IL-6 and IL-10 can be used as predictors for expedient diagnosis of patients with higher risk of deterioration. Hyper-inflammatory status in patients with severe COVID-19 is to be mitigated to alleviate signs and symptoms in cytokine storm. In case of deterioration of oxygenation and rapid progression of imaging (CT) findings, glucocorticoids can be used for a short time (3-5 days) for patients in whom overactivation of the body's inflammatory response is suspected. On the other hand, interleukin-6 receptor antibodies tocilizumab, sarilumab, siltuximab can be used as immunomodulators, to suppress inflammation and to alleviate fever and other manifestations of immune response. Their beneficial efficacy is especially remarkable during the cytokine storm period. It should be kept in mind that the agents to be used in the management of any given patient should be tailored for each situation.

Acute ischemic stroke is the most common manifestation of cerebrovascular disease, which ranks the first to make an adult become bedridden and/or out of productive life. Antiplatelet therapy has long been demonstrated to alleviate the risks of recurrent untoward events, especially in the setting of secondary prevention. In the last decade it has been proved that dual antiplatelet therapy (DAPT) appears to be more efficacious than monotherapy with aspirin. Clopidogrel (CLP) -an irreversible inhibitor of the platelet P2Y12 adenosine diphosphate receptor- is licensed in adults for the prevention of atherothrombotic events in patients suffering from MI, ischemic stroke (from 7 days to 6 months) or peripheral arterial disease. The recommended dose is 75 mg as a single daily dose, taken with or without food. This review is designed to encompass use of the agent comprehensively and delineates a frame in which clinicians can view as a guide in their routine clinical practice.