The excellent conductivity and versatile surface chemistry of MXenes render these nanomaterials attractive for sensor applications. This mini-review puts recent advances in MXene-based sensors into perspective and provides prospects for the area. It describes the attractive properties and the working principles of MXene-based sensors fabricated from a MXene/polymer nanocomposite or a pristine MXene. The importance of surface modification of MXenes to improve their affinity for polymers and to develop self-healing and durable sensors is delineated. Several novel sensor fabrication methods and their challenges are discussed. Emerging applications of MXene-based sensors including moisture, motion, gas, and humidity detection as well as pressure distribution mapping are critically reviewed. Potential applications of MXene-based sensors in the food industry to monitor food materials and production plants are highlighted.