Cancer registries are most important to predict and treat the cancer disease. Numerous solutions are available in research to analyze the data in cancer registries. However, there is a lack of well defined data model since there is a link to external web pages. In order to overcome this issue a system is proposed to represent the cancer data using a semantic data model. The data model uses a Resource Description Framework (RDF) format to represent the data from the local cancer databases. It also uses an optimized Querying of the semantically represented data using SPARQL query language. The optimization of the queries is done with the Modified shuffled frog leaping algorithm(MSFL). This helps in treatment of cancer patients in an easy way.