Aims: Isolation of Isocarpine From Adenocarpus Complicatus. Background: Adenocarpus Complicatus L. is one of Adenocarpus genus which has about 50 species, from Fabaceae (Papilionaceae) family. This plant found in the Mediterranean basin as southern west part of Europe and North Afric forestes. Objective: Isolation of Isocarpine From Adenocarpus Complicatus as Anticandidal Agent method: A new piperidine alkaloid Isocarpine was isolated from the aerial parts of Adenocarpus Complicatus L., which gross in Syria. The structure of the new compound was determined by UV, IR, EI-Ms, 1H-NMR, 13C-NMR, DEPT-135, DQF-COSY and HMQC. Results: The anticandidal activity of isocarpine was screened against 38 Candida strains and showed remarkable inhibitory effect compared with fluconazole as antifungal reference drug. Conclusion: Isocarpine is antifungal agent.