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Toluene is an aromatic hydrocarbon found in nature mainly in crude oil. Since it is a good solvent and has less toxic effects, it is preferred to be used instead of benzene in the industry. Toluene causes damage to the lungs and nervous system by contaminating chronically or acutely, especially through the respiratory tract. Resveratrol (RES) which is found in many fruits, especially grapes, provides antioxidant support to the body and shows protective properties against harmful substances. The aim of this study is to examine the negative effects of toluene on lactate dehydrogenase (LDH) activity in blood, liver and muscle tissue and to investigate the protective effects of RES against toluene. In the study, rats were divided into two groups as control and experimental groups. The first experimental group was injected with toluene at a dose of 900mg/kg intraperitoneally for 6 days. While the 2nd experimental group was given the same dose of toluene and 5mg/kg RES, the 3rd experimental group was given the same dose of toluene with 10mg/kg RES, the 4th experimental group was given the same dose of toluene and 20mg/kg RES. In the study two control groups, serum physiological and ethanol control groups, were used. After 6 days, all rats were killed by cervical dislocation. Blood, liver and muscle tissues were rapidly extracted from rats. LDH activities were determined. As a result, it was seen that toluene increased LDH activity and RES played a regulatory role in LDH activity.

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