A predictive model to estimate post-donation glomerular filtration rate (eGFR) and risk of CKD at 1-year was developed from a Toulouse-Rangueil cohort in 2017 and showed an excellent correlation to the observed 1-year post-donation eGFR. We retrospectively analyzed all living donor kidney transplants performed at a single center from 1998 to 2020. Observed eGFR using CKD-EPI formula at 1-year post-donation was compared to the predicted eGFR using the formula eGFR (CKD-EPI, mL/min/1.73 m2) = 31.71+ (0.521 × preoperative eGFR) − (0.314 × age). 333 donors were evaluated. A good correlation (Pearson r = 0.67; p < 0.001) and concordance (Bland-Altman plot with 95% limits of agreement −21.41–26.47 mL/min/1.73 m2; p < 0.001) between predicted and observed 1-year post-donation eGFR were observed. The area under the ROC curve showed a good discriminative ability of the formula in predicting observed CKD at 1-year post-donation (AUC = 0.83; 95% CI: 0.78–0.88; p < 0.001) with optimal cutoff corresponding to a predicted eGFR of 65.25 mL/min/1.73 m2 in which the sensibility and specificity to predict CKD were respectively 77% and 75%. The model was successfully validated in our cohort, a different European population. It represents a simple and accurate tool to assist in evaluating potential donors.

<i>Lautropia mirabilis</i> is a gram-negative coccoid bacterium isolated from oral and upper respiratory sites with unclear pathogenic potential. We present an exceedingly rare case of peritoneal dialysis-associated peritonitis due to <i>L. mirabilis</i> in a patient with a recent history of periodontal infection, successfully treated with intraperitoneal antibiotics. We propose that clinicians consider this organism as a potential cause of illness.

Background: Hemodialysis (HD) patients with atrial fibrillation (AF) have a particularly high risk of stroke and bleeding, but no high-quality evidence-based recommendations exist to properly manage these patients. Objectives:We aim to evaluate the ischemic versus the hemorrhagic risk in a HD population with AF. Methods:We selected incident patients that started hemodialysis between 2011 and 2015. All patients that had AF before HD, or developed AF during the follow-up, were included. Both CHA 2 DS 2 -VASC and HAS-BLED scores were calculated at the time of beginning of HD or AF diagnosis and correlated with the outcomes using a logistic regression model. The outcomes were hemorrhagic events, ischemic events and death related to any of these events. A p-value < 0.05 was set as statistically significant.Results: Forty-six patients were included. Most of them had had AF before they started hemodialysis. Twentytwo patients were on oral anticoagulation (OAC). There was no significant difference between the incidence of ischemic and hemorrhagic events, regardless of the use of OAC. Previous stroke, transient ischemic attack, and thromboembolic event significantly increased the risk of an ischemic event (OR 6.78, p=0.028). Conclusions:In this population, we did not observe any difference between the incidence of ischemic and hemorrhagic events, which was also true in patients with OAC. Therefore, the benefit of OAC in such patients remains questionable. However, patients with previous stroke, transient ischemic attack, or thromboembolic event seem to have a higher risk of new ischemic events and might benefit from anticoagulation.

Background: Living donor kidney transplantation (LDKT) is the best treatment for end-stage kidney disease (ESKD). Long term follow-up data of the donors are reassuring but some donors will develop chronic kidney disease (CKD) and, rarely, ESKD. Precise tools to define these risks are lacking.A predictive model to estimate the 1-year post-donation glomerular filtration rate (eGFR) and risk of CKD was developed from a Toulouse-Rangueil cohort in 2017[1] and has been shown to have good correlation to the observed 1-year post-donation eGFR [2, 3].We aimed to externally validate this predictive tool in the a cohort of patients who underwent LDKT at our center. Methods: Retrospective analysis of the 364 LKD at our center from 1998 to 2020. After exclusion of 33 donors, in whom eGFR at 1-year was missing, the remaining 333 donors were included in this study. Observed eGFR using CKD-EPI formula at 1-year post-donation was compared to the predicted eGFR using the formula developed in Toulouse-Rangueil: postoperative eGFR (CKD-EPI, mL/min/1.73m 2 ) = 31.71 ± (0.521 × preoperative eGFR) -(0.314 × age). The ability of this formula to predict the observed GFR was analyzed by Pearson correlation, agreement was evaluated by the Bland-Altman plot and discriminative ability to predict CKD3-5 by the area under the receiver operating characteristic (ROC) curve and by plotting calibration. Results: Patients' characteristics of the 333 LKD are shown in table 1. Mean donor age was 47.3±10.6 years-old and most were female (71%). A good correlation (Pearson r = 0.67; P < 0.001) and concordance (Bland-Altman plot with mean difference of observed-predicted eGFR = +2.33 mL/ min/1.73 m 2 ; 95% limits of agreement -21.41 to 26.47 mL/min/1.73m 2 ;P < 0.001) were seen between predicted and observed 1-year post-donation eGFR. Area under ROC curve (AUC) showed a good discriminative ability of the formula in predicting observed CKD at 1-year post-donation (AUC = 0.83; 95% CI: 0.78-0.88; P<0.001), as shown in Figure 2, with optimal cutoff corresponding to a predicted eGFR of 65.25.7 mL/min/1.73 m 2 (5.25ml above the equality cutoff), for which the sensibility and specificity to predict CKD were respectively 77% and 75%. Calibration curve, shown in Figure 3, exhibited an excellent prediction with slope = 1.000 and CITL = 0.000. Conclusions: The formula developed in Toulouse-Rangueil was successfully validated in our cohort, a different European population than previous described [2, 3]. We must, anyway, emphasize that the optimal value of predicted eGFR was around 5 ml/min higher than the equality cutoff for CKD3-5 detection at 1-year, an outcome that was correctly predicted (both its presence or absence) in every 3 out of 4 donors. This model represents a simple and accurate tool that may be used to assist in the evaluation of potential donors, particularly in the setting of current increasing donor age.

Paraneoplastic syndromes, such as myasthenia gravis, pure red-cell aplasia and systemic lupus erythematosus are well-documented in thymoma. Association with glomerulopathies is rare and may occur several years after thymectomy. We report a case of a 60-year-old male presenting with nephrotic syndrome after thymectomy due to thymoma. The kidney biopsy showed minimal change disease. The patient went into complete remission after treatment with corticosteroids. The pathogenesis of glomerular lesions associated with thymic disease remains controversial.