No abstract

1Oral administration of single doses of bopindolol (1-4mg) caused significant reductions in the rises of systolic blood pressure and heart rate produced by exercise; only the reduction in the rise of heart rate was significantly dose-related. 2 Resting heart rate was reduced by bopindolol. There were small effects on resting blood pressure. 3 Bopindolol caused a significant attenuation of the rise in plasma renin activity produced by passive head-up tilting to 75-85 degrees. 4 Bopindolol produced a dose-related attenuation of the increase in pulse rate evoked by passive tilting. 5 All effects 1-4 were maintained for at least 24 h. 6 There was no measurable effect on plasma potassium concentration, peak flow rate or forced expiratory volume (FEV,).