Introduction: -Chronic obstructive pulmonary disease (COPD) has effects that seems to be related with systemic inflammation. The objective of the current study was to find the relationship of metabolic syndrome and C-reactive protein (CRP) levels, as a marker of systemic inflammation in stable COPD patients with different severity levels and in age and sex matched control group .Materials and  Methods:-100 stable COPD patients and 50 control subjects were included in the study. The severity level in patients with COPD were determined according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria. ATP III (The National Cholesterol Education Program’s Adult Treatment Panel III) was used in diagnosis of metabolic syndrome. Hs-CRP levels were measured in venous samples of patients and control subjects.  Results: - The frequency of metabolic syndrome was found higher in-patient group than control subjects, especially in GOLD stages I, II (p= 0.004). Abdominal obesity, hypertension, hyperglycaemia components of metabolic syndrome were significantly more prevalent in-patient group (p< 0.0001). Increased CRP levels were higher in control and patient groups in all GOLD stages, with metabolic syndrome than without metabolic syndrome (p= 0.046, p= 0.216, p< 0.001, p= 0.05, p= 0.466).

The concept of Bifocal osteos1ynthesis is distraction at the Osteotomy site and compression at the non-union site with rhythmical distraction leads on the neo-osteogenesis and consolidation of cortectomy site. Transporting a segment of bone increases the vascularity of the fracture ends. Once the vascularity of the fracture ends increases, the infection will be eradicated and there will be healing of non-union. Daring transportation phase for bone lengthening their Wet pin tract infection and loosening in two cases for which pin Tension was done. ln all cases, neither there was infection at the Corticectomy site nor at the distraction sites. After a period of Waiting for consolidation to occur, the final result of the healing of the osteotomy was adequate in all cases. The cases (seven) with limb length discrepancy up to 2.5 cms in lower limb managed with modified footwear with heel and sole raise. One case of femur nonunion had angular deformity of 15 degrees. Six cases had knee stiffness; three cases had ankle stiffness. There was no neurological or vascular injury as a result of instrumentation. Bone healing index was (days of fixator use/centimeters of length gain) 69.1 days/cm.

Histopathologic ally in patient with diabetes the basement membrane is fragile in cornea which leads to recurrent corneal erosion. it was observed that reflex tearing was decreased & associated ocular surface diseases leads to a state of dryness in eye with diabetic patient. There is a close relationship between diabetic retinopathy and Kerato conjunctivitis Sicca (P< 0.006) with no laser Rx in diabetic eye in comparison to laser treatment. The present study on clinicopathological evaluation of dry eye status in diabetes mellitus was carried out in department of ophthalmology V.S.S.M.C.H, Burla between June 2006 - June 2008 with active co-ordination of the department of ophthalmology and pathology.

BackgroundThe increased prevalence of knee trauma predominantly adds to the anterior cruciate ligament (ACL) tear frequencies that require single-or double-bundle reconstructive surgeries. Few studies have demonstrated the superior results of double-bundle reconstruction compared to single-bundle approaches. This study investigated the knee function improvement capacity of both reconstruction techniques in patients with ACL tears. MethodsThirty cases with ACL tears have been enrolled and segregated equally in distinct (single-bundle versus double-bundle) batches. The diagnostic assessments were undertaken through comprehensive clinical history, knee radiographs, Lysholm scoring, the International Knee Documentation Committee (IKDC) scale, the Lachman analysis, the International Knee Documentation Committee (IKDC) scale, and the pivot shift method. ResultsAfter one year, there was a significant enhancement in the postoperative versus preoperative Lysholm scores in the single-bundle (58.5 ± 21.2 vs. 82.4 ± 26.2, p<0.001) and double-bundle (86.4 ± 22.8 vs 60.3 ± 19.2, p<0.001) groups. There was a significant improvement in the IKDC scores after a follow-up period of one year (p-value: 0.012 and p-value: 0.002, respectively) in both of the study batches. After a year of follow-up, Lysholm scores (p=0.352) and IKDC scores (p=0.574) between the study groups (82.4 ± 26.2 vs. 86.4 ± 22.8) were comparable. ConclusionThe clinical outcomes remained comparable between subjects with single-bundle reconstruction versus double-bundle reconstruction subjects with ACL injuries. Findings were similar between the groups after one year and two years of surgical interventions.

Soft tissue loss with multiple sinuses, osteomyelitis, osteoporosis, complex deformities with limb length inequality, stiffness of the adjacent joints and multi drug resistant infection all complicate treatment and recovery. Aim of the study is to observe the role of Orthofix limb reconstruction system as a treatment in non-union with bone loss and major soft tissue defect due to fresh fractures. The method of treatment of infected non-union by the Limb Reconstruction System with a predictable healing of nonunion and control of infection is well shown in this study.