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ABSTRACT:The stress response is the name given to the hormonal and metabolic changes which follow injury or trauma. The systemic reactions to surgical injury encompass a wide range of endocrinological, immunological and haematological effects. The ability of anaesthetic agents modifies the endocrine and metabolic responses have been studied enthusiastically. This research describes the endocrine and metabolic changes which occur during different types of surgical techniques, effects of anaesthetic and analgesic regimens to modify their responses. OBJECTIVES: The present study aimed to evaluate the effects of stress response on blood glucose levels and hemodynamics in patients undergoing open Laparotomy surgeries v/s laparoscopic surgeries. METHODS: Sixty surgical patients were enrolled in this clinical trial. The pulse, BP records were taken and blood sugar levels were tested peri-operatively. RESULTS: The results were analyzed and found that raise pulse rate, blood pressure and blood sugar levels due to stress in proportionate to surgical trauma, and duration of surgery under anaesthesia. Blood sugar levels gradually increased 90.5±4.88 to 115±7.18 and at post op119.4±6.93 in laparotomy group when compared to 91.07±4.93 to 118.33±5.06 and at post-op120.1±4.51 in laparoscopy group. CONCLUSION: Lap surgery causes minimum tissue injury and less stress response more so during postoperative period.

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