Objective: To compare reproductive outcome in women with uterine anomalies and women with a normal uterus, and evaluate the effect of resectoscope metroplasty. Methods: The pregnancy outcomes, past and present, of 105 women with congenital uterine anomalies were compared with those of 182 women with a normally shaped uterus. The outcomes of 25 women with septate and bicornuate uteri before and after resectoscope metroplasty were also analyzed. The χ 2 and Mann-Whitney U test were used for statistical analysis, with P b 0.05 considered statistically significant. Results: Uterine anomalies were associated with higher rates of spontaneous abortion, preterm delivery, intrauterine growth retardation, breech presentation, and cesarean delivery (P b 0.001). The highest incidence of early spontaneous abortion was noted among women with septate uteri, and the highest incidence of preterm labor was noted among women with arcuate or bicornuate uteri. Among women with arcuate uteri, significantly lower gestational age and birth-weight were observed compared with any other type of adverse outcome. Compared with their previous pregnancies, the abortion rates were lower and delivery rates were higher in women who conceived following hysteroscopic metroplasty (P b 0.001). Conclusion: Resesctoscope metroplasty significantly improved pregnancy outcome in women with uterine anomalies.

The aim of the study was to investigate whether altered adipose tissue secretion of various adipokines is secondary to obesity, hyperandrogenism, and hyperinsulinemia or intrinsic to polycystic ovary syndrome (PCOS). This cross-sectional study included 151 women diagnosed with PCOS by the Rotterdam criteria and 95 healthy women matched by age, body mass index (BMI), and waist-to-hip ratio (WHR). Clinical, biochemical, and hormonal characteristics were assessed. Serum concentrations of ghrelin and adiponectin were found to be significantly lower and concentrations of leptin and resistin significantly higher in women with PCOS than in healthy women matched by age, BMI, and WHR. A PCOS diagnosis made the largest contribution to predicting serum levels of leptin, adiponectin, resistin, and ghrelin in all stepwise multiple regression models, which included PCOS diagnosis, BMI, WHR, luteinizing hormone, total testosterone, free testosterone and homeostatic model assessment of insulin resistance as independent predictors. Leptin, adiponectin, ghrelin and resistin levels may serve as independent biomarkers for the diagnosis of PCOS.

Improving a low birth rate in females with SW 21-OHD remains a problem and new approaches are required. If the mother has 21-OHD (even nonclassical 21-OHD), pre-conception counselling and paternal genotyping are advisable and prenatal dexamethasone therapy should be considered.

COVID-19 je bolest uzrokovana novim koronavirusom nazvanim SARS-CoV-2. Virus se iznimno brzo proširio cijelim svijetom te tako predstavio veliki izazov svim zdravstvenim sustavima. Budući je riječ o novootkrivenom virusu, veliki se napori još uvijek ulažu u razumijevanje virusa i bolesti koju uzrokuje te potrazi za učinkovitim lijekom/cjepivom. O COVID-19 i trudnoći još uvijek nedostaje informacija zbog nedostatnog broja slučajeva opisanih u literaturi te prekratkog razdoblja trajanja bolesti. U daljnjem smo tekstu opisali trenutne spoznaje o utjecaju virusa na trudnoću, porođaj i postpartalno razdoblje koristeći podatke sa službenih stranica i znanstvenih radova objavljenih do 9. svibnja 2020. godine. Klinički je tijek bolesti kod trudnica sličan onome u općoj populaciji. Loš utjecaj virusa na tijek i ishod trudnoće još uvijek nije dokazan. Još uvijek nema sigurnih dokaza o vertikalnoj transmisiji niti transmisiji virusa putem majčinog mlijeka.