Mutations inactivating the STS gene cause X-linked ichthyosis (XLI), whereas null mutations in the FLG gene cause ichthyosis vulgaris. Two brothers presented with XLI. One had a typical fine scaling, and the other was much more severely affected. Both patients carried STS missense mutation T165I. Furthermore, the more severely affected patient also carried heterozygous FLG mutation R501X, which was absent from his mildly affected brother. These data suggest that disrupting epidermal differentiation via different pathways can increase phenotypic severity. Owing to the high population frequency of FLG mutations, filaggrin is a possible genetic modifier in other genodermatoses.

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This essay considers the movement away from a feminism based upon liberal political principles, such asJohn Stuart Mill espoused, and towards a radical feminism which seeks to build upon more recent explorations of psychology, biology and sexuality. It argues that some of these moves are philosophically suspect and that liberal feminism can accommodate the more substantial elements in these radical lines of thought. (11

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