Antipsikotik ilaçların kullanımı sırasında kan lökosit sayısında azalma görülebilmektedir. Bu tür durumlarda hastanın tedavisi kesilebilir ya da değiştirilebilir ve kan sayımı değerleri yakından izlenir. Ancak bu olgu sunumunda olduğu gibi tedavi değişikliklerinin kan tablosunda düzelmeyi sağlamadığı durumlarda, lityumla güçlendirme tedavisi düşünülmelidir. Bu olgu bildiriminin amacı, tipik ve atipik antipsikotik ilaçlara bağlı gelişen inatçı nötropeni olgularında tedaviye lityum eklenmesinin yararlı olabileceğine dikkat çekmektir.Anahtar kelimeler: Antipsikotik, lityum, nötropeni ABSTRACT Addition of lithium therapy in a patient with persistent neutropenia triggered with antipsychoticsDecrease in leukocyte count might be seen during the use of antipsychotic medications. In such cases, treatment can be stopped or changed and blood count values must be closely monitored. As in this case report, however, if changing the treatment doesn't provide improvement in blood counts, lithium augmentation can be considered. The objective of this case report is to point out that the addition of lithium therapy may be beneficial in patients with persistent neutropenia related to typical and atypical antipsychotic drugs.
<b><i>Introduction:</i></b> Despite the similarities in poor social competence and clinical manifestations of poor social behavior, no study has compared the theory of mind performance between social anxiety disorder (SAD) and schizophrenia, considering the effect of social-evaluative anxiety and neurocognitive functions. In our study, we aimed to compare the theory of mind functions and social-evaluative anxiety between patients with SAD and schizophrenia and healthy controls and to examine the relationship between the theory of mind, neurocognitive skills, and social-evaluative anxiety. <b><i>Methods:</i></b> Thirty-four consecutive patients with schizophrenia, 29 patients with SAD, and 30 controls matched by age, education level, and sex were enrolled in the study. Structured Clinical Interview for DSM, Beck Depression Inventory, Liebowitz Social Anxiety Scale, Theory of Mind measures (Reading the Mind in the Eyes Test, Hinting Task, Faux Pas Test), Social Appearance Anxiety Scale, Fear of Positive Evaluation Scale, Fear of Negative Evaluation Scale-Short Form, and neuropsychological tests were administered to all participants. <b><i>Results:</i></b> A greater significant deterioration in theory of mind and neurocognitive functions was found in patients with schizophrenia compared to those with SAD and healthy controls. Social evaluation anxiety was highest in patients with SAD. Although social-evaluative anxiety was associated with the theory of mind function in schizophrenia, only fear of positive evaluation was associated with SAD. In all groups, neither theory of mind nor neurocognitive ability measures were correlated with social anxiety levels and related symptoms. <b><i>Conclusions:</i></b> The impaired theory of mind functioning detected in our study is more prominent in the schizophrenia group and largely independent of anxiety in schizophrenia and SAD. Although social evaluation anxiety, as a transdiagnostic concept, seems to be independent of theory of mind function in general, fear of positive evaluation seems to be associated with hinting in both disorders.
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