A field experiment was conducted during kharif season of 2021, at crop research farm of Department of Agronomy at Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj in North Eastern plains of Eastern Uttar Pradesh with the objective to study the effect of bio fertilizer and spacing on growth, yield and economics of Pearl millet (Pennisetum glaucum L.) Var. VARUN - 666 under Randomized block design comprising of 9 treatments of which treatments (T1-T9) with different bio fertilizer combination of Azatobacter and Azospirillum along with spacing which are replicated thrice. The experimental results revealed that Application of Azotobacter @ 12.5g/kg +Azospirillum @ 12.5g/kg + 60 cm ×15 cm recorded significantly higher plant height (210.20 cm), Number of leaves/hill (40.3), Highest plant dry weight (49.49 gm), number of tillers/hill (3.3), number of ears/hill (2.43), number of grains/ear head (2097.33), grain yield (2.77 t/ha), straw yield (3.91 t/ha net return (Rs.1,03,453/ha), gross return (Rs.1,41,440/ha) and benefit: cost ratio (2.72).

The field experiment was conducted during Rabi 2021-2022 genotypes at Wheat Breeding experimental Field, Naini Agriculture Institute, SHUATS, Prayagraj, Uttar Pradesh. The Soil of the experimental plots was sandy loam in texture with neutral soil reaction (pH 6.7). The experiment was laid out with six genotypes (NERI-301, NERI-302, NERI-303, NERI-304, NERI-305 and NERI-306) in a Randomized Block Design with four replications. Study revealed that growth parameters viz., higher plant height (105.26cm), number of effective tillers/hill (10.00/hill), and plant dry weight (22.13 g/plant) were recorded significantly higher for the genotype NERI-305.For yield attributing parameters viz., number of effective tillers (6.55/hill), number of grains/spike (63.07/spike),and test weight (49.38 g) were significantly highest for the genotype NERI-304, and yield parameters viz, grain yield (4.74 t/ha), harvest index (41.52%) were recorded significantly higher for the genotype NERI-304. spike length (13.35 cm) and straw yield (6.69t/ha) were r significantly highest for the genotype NERI-301. From the above findings gross return (1,18,500.00 INR/ha), net return (82,314.00 INR/ha) and Benefit cost ratio (2.27) were significantly highest for the genotype NERI-304.The genotype NERI-304 was found to be more potential as well as economically viable and productive over rest of the  genotypes.