The purpose of our study is to determine the Glycemic Indexes (GIs) of three Algerians varieties of dates in healthy subjects evaluate the satiety and effect on arterial pressure after their consumption. We have first documented the chemical composition of the dates. 10 healthy subjects consumed the dates (carbohydrates content of 50 g) in order to determine the GIs. The responses of glycaemia were monitored during two hours after the dates taking and compared to the reference glucose. In a randomized trial, 20 healthy adults consumed the dates after 12h of fast. We reported the level of satiety on a Visual Analog Scale for 2h further to the ingestion of the dates. Furthermore, 28 normotensives and 45 hypertensive individuals ingested the three varieties in randomized order during 21 days to assess their impact on the Pressure Arterial Systolic (PAS) and Pressure Arterial Diastolic (PAD). We noted significant differences (p<0.05) for the different fractions of sugars, soluble fibers, polyphenols, K + , Mg 2+. The low GIs are denoted among 44.31-52.35, deducting a moderate impact on blood glucose level. The dates reduced hunger and increased satiety. Our varieties studied following their ingestion induced a significant hypotensive activity (p<0.05) on the PAS and, PAD from hypertensive subjects.

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Introduction. The current study was conducted in order to evaluate in vitro the phytochemical profile and antibacterial activity of Algerian palm dates Phoenix dactylifera L. Materials and methods. Qualitative and quantitative (total polyphenols, flavonoids and antioxidant activity)phytochemical analysis were performed on aqueous and methanolic extracts of seven varieties of dates as the evaluation of antibacterial activity against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 strains. Results and discussion. Phytochemical screening of aqueous and methanolic extracts showed the presence of several families of chemical compounds such as catechin tannins, saponins and terpenoids in the seven varieties of dates. The screening of these extracts reveals slight qualitative differences with a greater presence of saponins in the aqueous extract while terpenoids are present in large quantity in the methanolic extract. A quantitative characterization of extracts showed significantly high levels (P<0.05) in the methanolic extract from: 85.8±0.8 to 275 ± 0.07 GAE/100g, 36.9 ± 0.3 to 70.1 ± 0.9 QE/100g and 18.5 ± 0.9 to 58.5 ± 0.5% vs. 66.1±0.2 to 189±0.09 GAE/100g, 29.1±0.5 to 50.8±0.6 QE/100g and 14.7±0.4 to 41±0.1% in aqueous extracts for total polyphenols, flavonoids and reducing power respectively. The susceptibility of bacterial species to various extracts of Phoenix dactylifera L. fruits by agar well diffusion assay showed a maximum inhibition zone diameter (IZD) of 43.0 ± 1.0 and 26.3 ± 1.5 mm for the methanolic extract of the variety Tamesrit against S. aureus and E. coli strains respectively. The minimum inhibitory concentrations (MIC) ranged from 0.08 g / mL for the methanolic extract of the variety H'mira against E. coli to less than 0.04 g/mL for the methanolic extracts of the varieties Tamesrit, Akerbouch and Bent Kbala against S. aureus. Conclusion. Given the interesting contents of polyphenols, flavonoids and antioxidant activity in addition to the inhibitory power of date extracts, we can conclude that this product could be an excellent source of antioxidants and bioconservatives in food preparation.

Folic acid or vitamin B9 or pteroylglutamic acid, is a relatively simple molecule with two characteristics; firstly, it must be reduced by 2 or 4 hydrogen atoms to be metabolically active which makes it sensitive to oxidation and must be protected by ascorbic acid, secondly it may include in addition to the constituent residues of the molecule, 1-7 glutamate residue at one of its ends. These polyglutamate forms that make up the largest share of food folate, must be deconjugated by a specific enzyme present in the intestinal lumen before being absorbed in the jejunum. It is in the methylated form after passing through the enterocyte it is transported in the blood, excreted in bile and reabsorbed. It must be demethylated to integrate folic cell cycle and methyl transfer, that allows the synthesis of methionine (only possible in the presence of vitamin B12), purine, serine and especially thymidylic acid, constitutive DNA. As a methyl donor that plays a fundamental role in cerebral and nervous metabolism. Folates are involved in cell division thus; any folic acid deficiency causes a slowdown in rapid multiplication systems which may lead to red blood cell disorders (macrocytic anemia), immunity, and neural tube defects, in addition to physiological disorders (cardiovascular, cancer ...). Folic acid supplementation appears to allow the correction of these disorders.