Titanium and its alloys are potential materials for orthopedic implant applications due to their appropriate biological and mechanical behavior. As biocompatibility and biomechanical compatibilities are essential parameters for determining a biomedical implant's performance and service life, this research review article discussed the novel Ti alloys with nontoxic and biocompatible alloying elements with an elastic modulus similar to the bone. Among Ti alloys, β-Ti alloys are appropriate for load-bearing implant applications due to lower elastic modulus and nontoxic elements, including Ti, Ta, Nb, Zr, Sn, and Mo. Even though the β-Ti alloys possess a lesser elastic modulus compared to other metallic biomaterials, two issues associated with β-Ti alloys that result in implant failure are that they still possess a higher elastic modulus than human bone and they have insufficient strength. Alloy composition and thermomechanical processing characteristics play a vital role in altering the mechanical properties and microstructure of β-Ti alloys. Hence, this review article emphasizes the alloying and thermomechanical processing effects on the mechanical properties and microstructure of β-Ti alloys.

The development of biocompatible and biomechanical compatible metallic biomaterials is essential to fulfilling the needs of humanity, such as enhancing the lifespan and quality of human life and relieving pain. Biocompatibility resulting from non-toxic alloying elements and biomechanical compatibility resulting from low elastic modulus are crucial factors influencing the performance and service life of a biomedical implant. β-Ti alloys are the potential choice for biomedical load-bearing applications owing to their low elastic modulus and non-toxic alloying elements. Although the elastic modulus of β-Ti alloys is lesser than that of other metallic biomaterials, it is still greater than that of bone. So, there is a great demand for the synthesis of β-Ti alloys with low elastic modulus. Various phases significantly affect the elastic modulus of β-Ti alloys. Developing low elastic modulus β-Ti alloys through trial-and-error testing leads to more time-consuming and economically not feasible. So, this review article discusses various phases and alloy design methods for synthesising β-Ti alloys with low elastic modulus.