Introduction: Acne vulgaris is a disorder of the sebaceous gland affecting mostly the adolescent age. Although acne does not cause direct physical impairment, it can produce significant psychosocial stress. Due to the paucity of data, there is a poor understanding of etiopathogenesis, treatment and psycho-social impact of acne in the Nepalese population. This study is the first of its kind in Nepal.Objectives: To determine the beliefs, knowledge, misconceptions, myth, psycho-social impact about acne in recently joined undergraduate medical students attending basic science.Materials and Methods: A cross- sectional study was conducted in two medical colleges in Kathmandu affiliated to Kathmandu University (KU), which followed the same curriculum. Medical students of basic science were enrolled in the study. Self-administered questionnaire was used to collect the data regarding their belief and perception about acne.Results: A total of 247 students constituted the study population and female to male ratio was 1:1.62. Stress, oily skin, poor hygiene were the most common causative factors for acne. Belief and perception of acne included bad blood, menstrual cycle, eve teasing, evil eye. According to them, the best way to treat acne was herbal remedies. They liked to explain acne as being related to puberty, followed by dirty face. Psychological impact of acne was embarrassmentfollowed by lack of confidence and impaired social contact. Suicidal tendency due to acne was found in 3.6%.Conclusion: Misconception about acne are widespread and enduring among basic science medical students. Health education program on acne is needed to improve their condition.

Background: Police officer serves a vital role in maintaining safety and serve are role model for discipline throughout the world, they are non–intentional type sun exposure(NISE).The objective of our present study was to evaluate photo protector practice, knowledge in response to  Ultra violet Radiation ,Sunscreens and  sun related photodermatosis. Methodology: A cross sectional study was conducted in traffic police officer at different locations at Kathmandu. Data was collected by using self-administered questionnaires and interviewed by Dermatologist to establish their knowledge and behaviour and practice in relation to ultra violet radiation and photo-protection. Result: Out of 265 participants, mean age was 27.1 years. Respondent with graduation and master degrees had knowledge and practice toward UVR, follow by higher secondary education. Regarding the practice for photo protection only 59.6% had knowledge about sunscreen, 39.6% knowledge about Ultraviolet Radiation and 24.9% had knowledge about Ultra Violet Index .Skin problem like melasma, premature wrinkles, and hardening of skin, polymorphic light eruption, burning foot syndrome, dermatophytes, and varicose vein. Conclusion: Traffic police officers showed good practices in term of wearing hat, clothes that cover most of the body parts but poor practice over sunscreen, UVR, UVI. Lectures & seminar regarding the awareness and photo protection practice should be recommended. With lack of awareness among police officers and providing sunscreen for free should be considered by Police authorities. Similarly lectures & seminar on sun protection should be provided in regularly.

Background: Acne is a multi factorial disease ranging from a couple of comedones and pustules to severe nodulocystic fulminantacne. Isotretinoin (13-cis-retinoic-acid) drug affect all the factors involved in pathogenesis of acne and approved by Food and Drug Administration in 1982. It causes several dose-dependent mucocutaneous and systemic side effects and cost effectObjective: To assess and compare the efficacy and tolerability of two regimens (daily conventional and pulse dose) in moderate to severe acne vulgaris.Methodology: This is a prospective randomized comparative study in moderate to severe acne vulgaris in Kathmandu Medical College Teaching Hospital. The patients were randomly divided into two groups (A and B). In group A conventional dose of 20 mg of oral isotretinoin was given daily and in group B 20 mg of oral isotretinoin was given thrice (Pulse Dosage in alternate day) in a week for six months. The baseline haematological, biochemical and radiological (lumbosacral spine) was compare on first, third and six month.Results: Seventy-four patients were enrolled with mean age of 21.73 years. Patients with daily regimen show good response throughout the therapy for six months (1st, 3rd 6th months), where as those in pulse therapy show moderate to poor response during early month and gradually improve by end of sixth month. At end of sixth month, both the regimen show good response and was statistically significant.Conclusion: However, the pulse dose regimen makes the treatment more acceptable, for patients with acne than the classical standard daily regimen, in term of side effects and cost effectiveness and patient compliance. Journal of Kathmandu Medical CollegeVol. 7, No. 2, Issue 24, Apr.-Jun., 2018, Page: 68-74